The primary route of carbon entry into the tetrahydrofolate (THF) pool is via the serine hydroxymethyl transferase reaction. Which of the following is required to convert that initial form of the THF into the form that can donate carbons to de novo purine synthesis? (A) Glycine (B) FAD (C) Water (D) B12 (E) B6 plz type no hand written a short note plz

The primary route of carbon entry into the tetrahydrofolate (THF) pool is via the serine hydroxymethyl transferase reaction. Which of the following is required to convert that initial form of the THF into the form that can donate carbons to de novo purine synthesis? (A) Glycine (B) FAD (C) Water (D) B12 (E) B6 plz type no hand written a short note plz

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter27: Metabolic Integration And Organ Specialization

Section: Chapter Questions

Problem 20P: Figure 27.3 illustrates the response of R (ATP-regenerating) and U (ATP-utilizing) enzymes to energy...

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A point mutation in Hb diminishes hydrophobicity at the heme. Which of the following impacts would you predict? . Increased oxidation of Fe2+ and loss of O2 binding b. Decreased negative charges needed at the dimer/dimer interface to stabilize the T-state c. Decreased positive charges needed at the dimer/dimer interface to stabilize the T-state d. Shift the O2 binding curve of Hb to the left e. Decreased affinity for BPG in the T-state
Suppose a brief pulse of 14CO2 is taken up by a green plant.(a) Trace the 14C label through the steps leading to fructose-1, 6-bisphosphate synthesis, showing which carbon atoms in each compound should carry the label during the first cycle.(b) Will all molecules of fructose-1,6-bisphosphate carry two 14C atoms?Explain.
Which of the following statements about de novo purine synthesis is true? (A) Purine nucleotides are formed by separately synthesizing the phosphorylated ribose and the purine ring and then joining them together.(B) GMP is formed first and is used as a precursor to form AMP.(C) The synthesis of AMP from inosinate is driven forward by ATP hydrolysis. (D) GMP synthetase uses NADPH and glutamine to modify the inosinate ring to form GMP.(E) Replacement of the C-1 PPi on PRPP with an amine is required to construct the purine ring on the ribose sugar.
The M and H subunits of lactate dehydrogenase have very similar sizes and shapes but differ in amino acidcomposition. If the only difference between the two were that theH subunit had a glutamic acid in a position where the M subunithad a serine, how would the five isozymes of LDH separate on electrophoresis using a gel at pH 8.6?
Glucose labeled with C13 at carbon #1 is fed to cells undergoing glycolysis and fermentation to lactate. Which carbon on the lactate molecule will contain the C13 label? Will all of the lactate produced have the label? Would the answer be the same if galactose was fed to the same cells with C13 at C#1?
Figure 27.3 illustrates the response of R (ATP-regenerating) and U (ATP-utilizing) enzymes to energy charge. a. Would hexokinase be an R enzyme or a U enzyme? Would glutamine: PRPP amidotransferase, the second enzyme in purine biosynthesis, be an R enzyme or a U enzyme? b. If energy charge = 0.5: Is the activity of hexokinase high or low? Is ribose-5-P pyrophosphokinase activity high or low? c. If energy charge = 0.95: Is the activity of hexokinase high or low? Is ribose-5-P pyrophosphokinase activity high or low?
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Suppose there is a glycolytic-like pathway carried out by an alien species that uses analogous enyzme mechanisms to convert an 8-carbon sugar (① see structure below) to two 4 carbon fragments and then to a pyruvate analog. If the interconversion of the isomeric sugars ② and ③ is a reversible reaction similar to interconversion of glucose-6-phosphate and fructose-6-phosphate in glycolysis, draw the mechanism for the conversion of ③ to ② (reverse of the direction shown below) using the mechanism of phosphoglucoisomerase as your model. (Just skip the steps that lead to the ring opening/closing of glucose or fructose since this sugar is found in its open chain form).
Based on this information, what type of enzyme would ornithine decarboxylase be? I searched it up on Google and sources say it is a lyase because it catalyzes cleavage without H2O, but in equation 1, isn't water part of the reaction? Is decarboxylase still a lyase because water is a reactant, not a catalyst?
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Suppose a brief pulse of 14CO2 is taken up by a green plant.(a) Trace the 14C label through the steps leading to fructose-1, 6-sphosphate synthesis,showing which carbon atoms in each compound shouldcarry the label during the first cycle.(b) Will all molecules of fructose-1,6-bisphosphate carry two 14C atoms?Explain.