MATCH THE CORRECT WORDS TO THE DEFINITION A. spontaneous hydrolysis B. Random Generation C. C3 convertase D. membrane-attack complex E. Classical and lectin F. Antigen-antibody immune complex G. Microbial carbohydrates H. Decay-accelerating Factor (DAF) I. Short half-life J. Factor I The three major pathways of complement activation use different molecules and mechanisms to initiate a complement-mediatedimmune response.The classical pathway is activated by an interactionbetween C1q and a(n) _____.The initiation of the lectin pathway is dependenton lectins such as MBL binding toTo initiate the alternative pathway, C3 mustundergo to produce fragments that bindmicrobial surfaces and support the formation ofmembrane-bound C3 convertase.Although the initiating molecules differ, thepathways produce the same C3 convertase.Both passive and active mechanisms prevent hostcell destruction when complement activity is high.One passive mechanism is the of certaincomplement components such as the alternativepathway C3 convertase.One example of active regulation is cleavage ofmembrane-bound C3b by in the presence ofhost cell-specific cofactors.>

Answered: The three major pathways of complement…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter12: Body Defenses

Section: Chapter Questions

Problem 14RE

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Question

MATCH THE CORRECT WORDS TO THE DEFINITION

A. spontaneous hydrolysis

B. Random Generation

C. C3 convertase

D. membrane-attack complex

E. Classical and lectin

F. Antigen-antibody immune complex

G. Microbial carbohydrates

H. Decay-accelerating Factor (DAF)

I. Short half-life

J. Factor I

The three major pathways of complement activation use different molecules and mechanisms to initiate a complement-mediated
immune response.
The classical pathway is activated by an interaction
between C1q and a(n) _____.
The initiation of the lectin pathway is dependent
on lectins such as MBL binding to
To initiate the alternative pathway, C3 must
undergo to produce fragments that bind
microbial surfaces and support the formation of
membrane-bound C3 convertase.
Although the initiating molecules differ, the
pathways produce the same C3 convertase.
Both passive and active mechanisms prevent host
cell destruction when complement activity is high.
One passive mechanism is the of certain
complement components such as the alternative
pathway C3 convertase.
One example of active regulation is cleavage of
membrane-bound C3b by in the presence of
host cell-specific cofactors.
>

Expert Solution

Step 1

Complement-mediated immune response:

The complement system of the body which is a part of the innate immune response is activated when a foreign pathogen enters the body. As an effect of the complement system activation, the target cells are lysed. The pathogens are coated with complement proteins that help in their destruction.

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