Which of the following is not true about the complementsystem?(a) It is a set of more than 20 proteins that play a key rolein host defense by specifically acting in different waystoward different microorganisms.(b) Its general functions include enhancing phagocytosis byphagocytes, lysing microbes and enveloped viruses directly, and generating peptide fragments that regulateinflammation and immune responses.(c) It is a fast-acting innate host defense that works in a cascade.(d) There are three pathways classical, lectin, and alternative.(e) The effects of each activation pathways are the same.

Which of the following is not true about the complementsystem?(a) It is a set of more than 20 proteins that play a key rolein host defense by specifically acting in different waystoward different microorganisms.(b) Its general functions include enhancing phagocytosis byphagocytes, lysing microbes and enveloped viruses directly, and generating peptide fragments that regulateinflammation and immune responses.(c) It is a fast-acting innate host defense that works in a cascade.(d) There are three pathways classical, lectin, and alternative.(e) The effects of each activation pathways are the same.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 2QP: The Complement System Kills Microorganisms The complement system supplements the inflammatory...

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The Complement System Kills Microorganisms The complement system supplements the inflammatory response by directly killing microorganisms. Describe the life cycle of complement proteins, from their synthesis in the liver to their activity at the site of an infection.
What clinical symptoms can an inherited deficiency in complement components C3 or C4 lead to?
If a series of genetic mutations prevented some, but not all, of the complement proteins from binding antibodies or pathogens, would the entire complement system be compromised?
The classical complement pathway is initiated by C1q binding to the surface of a pathogen. In some cases, C1q can directly bind the pathogen, for instance by recognizing proteins of bacterial cell walls, but in most cases C1q binds to IgM antibodies that are bound to the pathogen surface. How does this IgM-binding feature of C1q contribute to rapid, innate immune responses rather than to slow, adaptive responses? C1q induces B lymphocytes to begin secreting antibody within hours of pathogen exposure. Natural antibody that binds to many microbial pathogens is produced prior to pathogen exposure. C1q binds to C-reactive protein which then binds to IgM on the pathogen surface. C1q directly induces inflammation, recruiting phagocytes and antibodies from the blood into the infected tissue. C1q binds to dendritic cells in the infected tissue, inducing them to secrete inflammatory cytokines.
Which of these statements about complement proteins C3a and C5a is false?a. They are released during the complement fixation process.b. They stimulate chemotaxis of phagocytic cells.c. They promote the activity of phagocytic cells.d.They produce pores in the victim plasma membrane.
It would be disastrous if a complement attack werenot confined to the surface of the pathogen that is the tar-get of the attack. Yet, the proteolytic cascade involved inthe attack liberates biologically active molecules at severalsteps: one that diffuses away and one that remains boundto the target surface. How does the complement reactionremain localized when active products leave the surface?
Which of the following does not describe the outcome of complement activation? a. chemotaxis b. opsonization c. vasoconstriction d. proteolysis e. membrane permeabilization.
List and describe the three outcomes of complement activation.
What triggers the alternative pathway for complement activation?
Which pathway of complement activation is depicted in this figure?
How is complement activation triggered in the classical complement pathway, and how does complement “know” what cells to attack?
Two of the major actions of complement are a. increased inflammatory response and cytolysis. b. recognition and destruction of a specific antigen and cytolysis. c. production of antibody and increased inflammatory response. d. release of cytokines to increase the immune response and production of antibody.