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The prospect of using gene therapy to alleviate genetic conditions is still a vision of the future. Gene therapy for adenosine deaminase deficiency has proved to be quite promising, but many obstacles remain to be overcome. Currently, the correction of human genetic defects is done using retroviruses as vectors. For this purpose, viral genes are removed from the retroviral genome, creating a vector capable of transferring human structural genes into sites on human chromosomes within target-tissue cells. Do you see any potential problems with inserting pieces of a retroviral genome into humans? If so, are there ways to combat or prevent these problems?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 16, Problem 13QP
Textbook Problem
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The prospect of using gene therapy to alleviate genetic conditions is still a vision of the future. Gene therapy for adenosine deaminase deficiency has proved to be quite promising, but many obstacles remain to be overcome. Currently, the correction of human genetic defects is done using retroviruses as vectors. For this purpose, viral genes are removed from the retroviral genome, creating a vector capable of transferring human structural genes into sites on human chromosomes within target-tissue cells. Do you see any potential problems with inserting pieces of a retroviral genome into humans? If so, are there ways to combat or prevent these problems?

Summary Introduction

To determine: The potential problems that are associated with inserting pieces of a retroviral genome into humans.

Introduction: Human genetic defects are corrected by using retroviruses as vectors. The procedure involves the removal of viral genes from the retroviral genome and then creating a vector that is capable of transferring human structural genes into sites on human chromosomes within target cells. The gene therapy has proved quite promising for the correction of adenosine deaminase deficiency.

Explanation of Solution

The vectors carry the designed DNA sequence or fragment from one organism to another. The examples of vectors are plasmids, cosmids, phagemids, and phages. The use of viruses also offers additional advantages as vectors. The virus consists of a strong promoter that can be recognized by eukaryotic polymerases. The genes carried by viral vectors are easily expressed in the host cells that receive the recombinant DNA. So, these are called expression vectors that are widely used in gene therapy...

Summary Introduction

To determine: Whether there are ways to combat or prevent the problems regarding insertion of retroviral genome into humans.

Introduction: Human genetic defects are corrected by using retroviruses as vectors. The procedure involves the removal of viral genes from the retroviral genome and then creating a vector that is capable of transferring human structural genes into sites on human chromosomes within target cells. The gene therapy has proved quite promising for the correction of adenosine deaminase deficiency.

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