Twist transcription factors (TF) play key roles in embryonic development and are largely undetectable in normal adult tissues; however, their expression is reactivated during tumor progression and correlates with invasive and metastatic lesions. Transcription of the Twist gene is activated by Wnt signals and the Twist TF represses the gene for E-cadherin. Answer the following questions as briefly as possible, based on what was presented in class, not an internet search (complex answers that go beyond class material may lose points) a. Outline the steps from the Wnt signal to the E-cadherin gene (inclusive); e.g., A → B → C (with some clarifications such as “binds to”, “activates”, “represses”) b. What are the normal cellular and embryonic (morphological) consequences of Twist expression? c. How would inappropriate expression contribute to cancer?
Twist transcription factors (TF) play key roles in embryonic development and are largely
undetectable in normal adult tissues; however, their expression is reactivated during tumor
progression and correlates with invasive and metastatic lesions. Transcription of the Twist
gene is activated by Wnt signals and the Twist TF represses the gene for E-cadherin.
Answer the following questions as briefly as possible, based on what was presented in class,
not an internet search (complex answers that go beyond class material may lose points)
a. Outline the steps from the Wnt signal to the E-cadherin gene (inclusive);
e.g., A → B → C (with some clarifications such as “binds to”, “activates”, “represses”)
b. What are the normal cellular and embryonic (morphological) consequences of Twist expression?
c. How would inappropriate expression contribute to cancer?
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