Vaccines are an attractive prophylactic treatment against both viral and bacterial diseases. A number of glycaconjugate vaccines using bacterial polysaccharide structures conjugated to protein carriers have been introduced into mass vaccination schemes with excellent results. (i) What differences are there in the immune response to a glycoconjugate vaccine as compared to a polysaccharide vaccine? These glycoconjugate vaccines has been used for 30 years without any change in their structures, while the composition of the flu vaccine, based on attenuated or killed virus particles, is changed from year to year. Discuss the reason behind this.
Vaccines are an attractive prophylactic treatment against both viral and bacterial diseases. A number of glycaconjugate vaccines using bacterial polysaccharide structures conjugated to protein carriers have been introduced into mass vaccination schemes with excellent results. (i) What differences are there in the immune response to a glycoconjugate vaccine as compared to a polysaccharide vaccine? These glycoconjugate vaccines has been used for 30 years without any change in their structures, while the composition of the flu vaccine, based on attenuated or killed virus particles, is changed from year to year. Discuss the reason behind this.
Chapter16: Adult And Pediatric Dosages Based On Body Surface Area
Section: Chapter Questions
Problem 18SST
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Transcribed Image Text:(a)
Answer all sections (i)- (Iv).
Below is given the structure of three anti-HIV drugs:
OH
Meo.
OMe
NH
Ph
Nevirapine
Atazanavir
Staudivine
(i)
Give the drug target and discuss the anti-HIV mechanism of each of these drugs.
Vaccines are an attractive prophylactic treatment against both viral and bacterial diseases.
A number of glycaconjugate vaccines using bacterial polysaccharide structures conjugated to
protein carriers have been introduced into mass vaccination schemes with excellent results.
What differences are there in the immune response to a glycoconjugate vaccine as compared to
a polysaccharide vaccine?
These glycoconjugate va
nes has been used for 30 years without any change in their
structures, while the composition of the flu vaccine, based on attenuated or killed virus particies,
is changed from year to year. Discuss the reason behind this.
(iv) Discuss why it has not been possible to develop a (part structure) vaccine against the HIV virus,
based on either I) viral protein structures or II) viral carbohydrate structures.
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