Need help with this question. Thank you :) (vi) The final step in your reaction sequence is alkylation with benzylbromide. Draw the structureof the final cyclic chiral product C. Indicate the chiral centre and give any important reactionconditions..N.COMMLDAPHCH,BrА+ LİB.The structure of C is; Question 1Alkylation of valerolactim ethers (1) is an attractive route to a-alkyl-ô-amino acids; importantbuilding blocks for medicinally important compounds. After discussion with your supervisor youdecide to test two compounds, lithium diisopropylamide (LDA) and n-propyllithium (n-PrLi), aspossible metalating reagents. The strategy isTo synthesise fresh solutions of LDA and n-PrLi.To test them in reactions with the valerolactim ether (1)To obtain the possible cyclic chiral product on alkylation with benzylbromideLOMEvalerolactim ether (1)

(vi) The final step in your reaction sequence is alkylation with benzylbromide. Draw the structure of the final cyclic chiral product C. Indicate the chiral centre and give any important reaction conditions. .N. LOME LDA PHCH,Br A C + LİBr

(vi) The final step in your reaction sequence is alkylation with benzylbromide. Draw the structure of the final cyclic chiral product C. Indicate the chiral centre and give any important reaction conditions. .N. LOME LDA PHCH,Br A C + LİBr

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter23: Amines

Section: Chapter Questions

Problem 23.58P

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Question

Need help with this question. Thank you :)

(vi) The final step in your reaction sequence is alkylation with benzylbromide. Draw the structure
of the final cyclic chiral product C. Indicate the chiral centre and give any important reaction
conditions.
.N.
COMM
LDA
PHCH,Br
А
+ LİB.
The structure of C is;

Question 1
Alkylation of valerolactim ethers (1) is an attractive route to a-alkyl-ô-amino acids; important
building blocks for medicinally important compounds. After discussion with your supervisor you
decide to test two compounds, lithium diisopropylamide (LDA) and n-propyllithium (n-PrLi), as
possible metalating reagents. The strategy is
To synthesise fresh solutions of LDA and n-PrLi.
To test them in reactions with the valerolactim ether (1)
To obtain the possible cyclic chiral product on alkylation with benzylbromide
LOME
valerolactim ether (1)

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