Vinblastine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related to Select one: O a. inhibition of DNA synthesis. O b. myosin denaturation and inhibition of cleavage furrow formation. O c. suppression of cyclin production. O d. inhibition of regulatory protein phosphorylation. O e. disruption of mitotic spindle formation.

Vinblastine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related to Select one: O a. inhibition of DNA synthesis. O b. myosin denaturation and inhibition of cleavage furrow formation. O c. suppression of cyclin production. O d. inhibition of regulatory protein phosphorylation. O e. disruption of mitotic spindle formation.

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter10: Cell Division And Mitosis

Section: Chapter Questions

Problem 1ITD: Biologists have long been interested in the effects of radiation on cells. In one experiment,...

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Biologists have long been interested in the effects of radiation on cells. In one experiment, researchers examined the effect of radium on mitosis of chick embryo cells growing in culture. A population of experimental cells was examined under the microscope for the number of cells in telophase (as a measure of mitosis occurring) before, during, and after exposure to radium. The results are shown in the Figure. What is the effect of radium exposure on mitosis? Source: R. G. Canti and M. Donaldson. 1926. The effect of radium on mitosis in vitro. Proceedings of the Royal Society of London, Series B, Containing Papers of a Biological Character 100:413419.
Characterize the differences between tumor cells and normal cells in terms of the following properties. In cancer cells, how might each of these properties contribute to tumor progression? a) contact inhibition b) autocrine stimulation c) apoptosis d) senescence due to telomere shortening e) genomic stability f) angiogenises g) metastasis
One important biological effect of a large dose of ionizing radiation (like X-rays) is to halt cell division. How does this occur? To answer this question, state the name and role of 2 specific and important proteins involved in the process. What happens if a cell has a mutation that prevents it from halting cell division after be irradiated? Be specific and detailed. An adult human who has reached maturity will die within a few days of receiving a radiation dose large enough to stop cell division. What does that tell you about cell division? In addition, name 2 different/unique cell types that would be primarily affected.
Which of the following is the primary method by which cyclin proteins are regulated to influence entry into the cell cycle or transition from one stage to the next? A. Transcriptional upregulation and translation followed by targeted ubiquitin-mediated degradation by a proteasome. B. Phosphorylation to regulate the activity of the kinase site. C. An activating phosphorylation and an inactivating phosphorylation. D. All of these are mechanisms that can be used to regulate cyclins.
Discuss the complete cell cycle in a human cell, mitosis and meiosis, and the regulatory components (i.e. the proteins associated with cellular checkpoints) of the cell cycle. Tumor growth results when the cell cycle checkpoints are ignored. Give an example of how tumor growth could result from either a loss-of-function or a gain-of-function mutation.
By what molecular pathway does loss of cell cycle regulation in an organism lead to cancer? What genetic changes can cooperate to accomplish the cancer cell’s escape from the normal balance of cell growth?
A researcher studying a line of cancer cells noticed that cellular content of RhoBTB3 and Cyclin E1 increase and decrease through the cell cycle. a. He hypothesizes that RhoBTB3 signaling regulates the production of Cyclin E1 and the entry of the cell into mitosis. Based on the data below, explain why his results do not support this hypothesis. Identify what conclusions are supported by this data. b. Suppose that the researcher can engineer a cell line in which RhoBTB3 expression can be induced by the addition of a drug. Design an experiment using this cell line to test whether RhoBTB3 regulates the production of Cyclin E1. Describe what results he can expect if his hypothesis is correct.
1.Colchicine is a type of drug that inhibits the microtubule formation during the cell division. Let’s say that the onion root tip (a place where most of the plant’s cells divide) was submerge in colchicine solution. a. How do you think will be the cell’s respond? Will it continue its cell division? Why or why not? b. Let’s say that the cells in onion root tip treated with colchicine were not halted at spindle checkpoint. What do you think will happen during the division?
In a dividing cell, the duplicated sets of chromosomes move along microtubules to opposite ends of the cell. How would you use an inhibitor to show that microtubules are essential for chromosome separation? What control treatment(s) would you use? What kind of cell junctions would you expect to find, and why, in a small animal where a chemical signal passes rapidly through cells to go from the head to the tail?
A Patients with an inherited cancer have a mutation in a zinc-finger motif of P21 (a cell-cycle regulatory gene). Which of the following is the most likely result of this A) Decreased binding of a transcription factor to a DNA sequence B) Enhanced binding of hormones to receptors C) Enhanced transport of a hormone receptor complex into the nucleus D) Stimulation of mRNA synthesis E) "Unzipping" of leucine-rich helices
Newly forming astral microtubules associate with dynein motor proteins, with the tail of the dynein bound to the plasma membrane. This association appears to be important in the distribution of astral microtubules to the polar regions (opposite “ends”) during spindle assembly.Now fast forward to the events of anaphase. In which phase of Anaphase (A or B) does the association between astral microtubules and membrane-bound dynein play a role? What is that role? (Your answer should incorporate information on how the directionality of dynein’s movement is involved in the process you describe.)
Explain why we can say that M-phase of the cell-cycle is triggered by a positive feedback loop. a) What would the consequences be if cohesins were working normally but condensins were not? and b) what stage of the cell cycle would this cause problems in? Why is it important for the centrosome to duplicate during G1-G2 (interphase) before M phase? The kinetochores serve as a link between the sister chromatids and the microtubules attached to the mitotic spindle. a) How are microtubules still able to exhibit dynamic instability after they are bound to the sister chromatids and b) why is this important to mitosis? As the name suggests, the Anaphase-promoting-complex (APC), promotes the 4th phase of mitosis by separating the sister chromatids so they can travel to separate poles of the cell, and prevents them from being re-zipped together. Describe how APC does these two things (Hint: one involves M-cyclin and the other involves…