Virtually all cancer treatments are designed to killcancer cells, usually by inducing apoptosis. However, oneparticular cancer—acute promyelocytic leukemia (APL)—has been successfully treated with all-trans-retinoic acid, which causes the promyelocytes to differentiate into neu-trophils. How might a change in the state of differentiation of APL cancer cells help the patient?

Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter5: Membranes And Transport
Section: Chapter Questions
Problem 1ITD: Some cancer cells are insensitive to typical chemotherapy. Research into the mechanisms underlying...
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Virtually all cancer treatments are designed to kill
cancer cells, usually by inducing apoptosis. However, one
particular cancer—acute promyelocytic leukemia (APL)—
has been successfully treated with all-trans-retinoic acid, which causes the promyelocytes to differentiate into neu-
trophils. How might a change in the state of differentiation of APL cancer cells help the patient?

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