The destruction of the various cyclins is commonly used to inactivate the Cdk/cyclin complexes. Why is it advantageous to inactivate these complexes via protein destruction instead of some other method that does not require the re-synthesis of a cyclin protein the next time the cell divides?

Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter5: Membranes And Transport
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Problem 1ITD: Some cancer cells are insensitive to typical chemotherapy. Research into the mechanisms underlying...
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The destruction of the various cyclins is commonly used to inactivate the Cdk/cyclin complexes. Why is it advantageous to inactivate these complexes via protein destruction instead of some other method that does not require the re-synthesis of a cyclin protein the next time the cell divides?

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Introduction

Cancer or tumor growth occurs when the cell cycle regulation mechanisms fail to stop the division of cells in a tissue. This uncontrolled growth could lead to benign or malignant tumors. Cells employ several mechanisms to have a check on the cell division. 

CDK is the abbreviation for cyclin-dependent kinases. These enzymes function in the regulation of cell cycle progression through various stages.

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