Although tobacco smoking is responsible for a large number of human cancers, not all smokers develop cancer. Similarly, some people who inherit mutations in the tumor-suppressor genes p53 or RB1 never develop cancer. Explain these observations.

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Chapter10: Cell Reproduction
Section: Chapter Questions
Problem 2VCQ: Figure 10.13 Rb and other proteins that negatively regulate the cell cycle are sometimes called...
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Although tobacco smoking is responsible for a large number of human cancers, not all smokers develop cancer. Similarly, some people who inherit mutations in the tumor-suppressor genes p53 or RB1 never develop cancer. Explain these observations.

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