We mentioned in the chapter opener (p. 1198) that tetrodotoxin has been synthesized using a Diels-Alder reaction. The one incorporated in the synthesis by M. Isobe involved the following diene and dienophile. Draw the curved arrow notation for this reaction. Br Br
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- Which of the following compounds can arise directly from a Diels-Alder reaction? Circle any structures that can. Then, identify the appropriate diene(s) and dienophile(s) that would lead to the compound. Pay attention to E-/Z- stereochemistry in all of the reactants. For those that cannot undergo a Diels-Alder reaction, please explain why.Curved arrows are used to illustrate the flow of electrons. Using the provided starting and producy structures, draw the curved electron-pushing arrows for the folloing reaction or mechanistic steps. Be sure to account for all bond-breaking and bond-making steps.Compounds containing triple bonds are also Diels–Alder dienophiles. With this in mind, draw the products of each reaction.
- Which compound(s) is (are) best suited for nucleophilic aromatic substitution reactions?Consider a traditional Diels Alder reaction noting it's methodology and synthetic tactical. Then propose an alternative, greener synthetic route to make the same product with near or same enantioselectivity.I know the product and the arrow pushing for both reactions, but I need assistance with the FMO energy diagrams. I know the first one is a normal Diels alder reaction and the second one is Inverse electron demand Diels–Alder reaction. But, I am confused about how to draw them out.
- What is the product E and how is it formed? Can this be explained using frontier molecular orbital analysis? What would the regiochemistry and stereochemistry be?This is a Diels-Alder reaction between furan + maleic anhydride (endo and exo products). For each cycloaddition product, draw in all hydrogen atoms, and write the molecular formula below.Please Explain in details and steps for this Diels-Alder reaction and the obtained product. i want the full mechanism also. thank you
- List down the following safety guidlines by doing the heat of reaction experiment:Does dehydrogenation of alkyl halides create Zaitsef or Hoffman products? In this example, which is created? I think it's Hoffman because there is a more stable/substituted option which is to put the double bond to the right of the positive charge instead of to the left. Or does it depend on the reactants? Further clarification is needed. Thank you in advance!Which of the following compounds (A, B or C) would be the one that is the majority product of this Friedel-Crafts alkylation?