What cellular mechanism(s) ensure that passage through the cell cycle is unidirectional and irreversible? What mo-lecular machinery underlies these mechanism(s)?
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What cellular mechanism(s) ensure that passage through
the cell cycle is unidirectional and irreversible? What mo-
lecular machinery underlies these mechanism(s)?
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- BPA is a chemical compound that has historically been used in themanufacture of plastic products. However, cells often mistake BPAcompounds for hormones that accelerate the cell cycle. Because ofthis, BPA is associated with an increased risk of certain cancers. Question: Why do you think that very small concentrations of BPA mighthave a large effect on the cell?Most general functions of a cell occur during G1 of interphase. What events that occur during other phases of the cell cycle might inhibit general metabolism?What from mitosis is triggered by mitotic CDK inactivationmainly brought about by mitotic cyclin degradation.
- Progression through the cell cycledepends on the phosphorylationof hundreds of different proteins bycyclin–Cdk complexes. What are themolecular mechanisms ensuring thatthese proteins are phosphorylated atprecisely the right time and place?BPA is a chemical compound that has historically been used in themanufacture of plastic products. However, cells often mistake BPAcompounds for hormones that accelerate the cell cycle. Because ofthis, BPA is associated with an increased risk of certain cancers. Question: How might BPA interact with the cell cycle and its checkpoints?At the checkpoints of the cell cycle, proteinscalled cyclins bind to________________ and activatereactions that enable the cell to proceed tothe next stage of the cycle.
- What is the order in which the following events occur during cell division: A. anaphase B. metaphase C. prometaphaseD. telophase E. lunar phaseF. mitosis G. prophaseWhere does cytokinesis fit in?Describe the cell cycle overall (not each phase). What is interphase, what are the G phases, and what is S phase?By what molecular pathway does loss of cell cycle regulation in an organism lead to cancer? What genetic changes can cooperate to accomplish the cancer cell’s escape from the normal balance of cell growth?
- The Cell Cycle: During what stage of the cell cycle is the nuclear material doubled? Are the stages of mitosis occurring simultaneously on a meristem? In what material is the coded information of the cell stored?Leland Hartwell, the third recipient of the 2001 NobelPrize in Physiology or Medicine, was acknowledged forhis characterization of cell cycle checkpoint pathways in the budding yeast S. cerevisiae. What is a cell cycle check-point pathway? When during the cell cycle do checkpointCytoskeletal elements play important roles in cell division. The mitotic spindle apparatus is made up of _____________ _____________ and pulls sister chromatids apart, whereas the contractile ring is made up of ______________ _____________ required for the separation of daughter cells at the end of the mitotic phase of the cell cycle