What are the most important steps in cell-cycle regulation? Give some explanations and present some factors leading to uncontrolled cell cycle.
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What are the most important steps in cell-cycle regulation? Give some explanations and present some factors leading to uncontrolled cell cycle.
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- What aspects of the cell cycle are controlled by the G1, G2, and M checkpoints? How are cyclins and cyclin-dependent protein kinases involved in cell cycle regulation at checkpoints?Briefly explain: What is meant by the term “cycle” in cell cycle? What is happening in the S phase and M phase?Leland Hartwell, the third recipient of the 2001 Nobel Prize in Physiology or Medicine, was acknowledged for his characterization of cell cycle checkpoint pathways in the budding yeast S. cerevisiae. What is a cell cycle check-point pathway?
- Describe the likely consequences of bypassing the G1 and G2 checkpoints in the cell cycle. Why do compounds like nonylphenol lead to the multiplication of abnormal cells?Benign and cancerous tumors occur when the cell cycle control mechanisms no longer operate correctly. What types of genes may be involved in these cell cycle control mechanisms?Explain how cyclin and cyclin-dependent kinases control the cell cycle.
- The cell-cycle control system is based on a connected series of biochemical switches which possess many important features that increase the accuracy and reliability of cell-cycle progression. DiscussDescribe how p53 functions to arrest cells in G1 and G2 stages of the cell cycle to regulate the progression to the S and M stages respectivelywhat are cell cycle checkpoints? Where are they found in the cell cycle? What do they check for?