What is a role of minor H antigens in skin graft rejection process?  What is a difference between cases of graft rejected rapidly vs graft rejected slowly?  What requirements have to be met to insure that graft will be tolerated?  What testing should be performed to prevent rejection?

Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter21: The Lymphatic And Immune System
Section: Chapter Questions
Problem 17RQ: The elimination of self-reactive thymocytes is called ________. positive selection. negative...
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Using the diagram below answer the following:

  • What is a role of minor H antigens in skin graft rejection process? 
  • What is a difference between cases of graft rejected rapidly vs graft rejected slowly
  • What requirements have to be met to insure that graft will be tolerated? 
  • What testing should be performed to prevent rejection? 
Skin graft to
syngeneic recipient
Skin graft to
allogeneic recipient
Skin graft to minor
H antigen incompatible
recipient
MHC
MHC
MHC
MHC
MHC
MHC
Graft tolerated
Graft rejected rapidly
Graft rejected slowly
% of 100-
grafts
surviving
50-
0-
60
Days after grafting
0 10
60
120 0 10
60
120 0 10
120
Transcribed Image Text:Skin graft to syngeneic recipient Skin graft to allogeneic recipient Skin graft to minor H antigen incompatible recipient MHC MHC MHC MHC MHC MHC Graft tolerated Graft rejected rapidly Graft rejected slowly % of 100- grafts surviving 50- 0- 60 Days after grafting 0 10 60 120 0 10 60 120 0 10 120
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  • What testing should be performed to prevent rejection? 
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