What is the first step in a base catalyzed aldol reaction? A. Protonation of Carbonyl group B. Elimination of Carbonyl with an alkene C. Formation of an Enolate D. Elimination of hydroxide E. Addition of nucleophile to R2C=O

What is the first step in a base catalyzed aldol reaction? A. Protonation of Carbonyl group B. Elimination of Carbonyl with an alkene C. Formation of an Enolate D. Elimination of hydroxide E. Addition of nucleophile to R2C=O

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter26: Aldol And Claisen Reactions

Section: Chapter Questions

Problem 7E

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Concept explainers

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.

Question

What is the first step in a base catalyzed aldol reaction?

	A.	Protonation of Carbonyl group
	B.	Elimination of Carbonyl with an alkene
	C.	Formation of an Enolate
	D.	Elimination of hydroxide
	E.	Addition of nucleophile to R₂C=O

Definition Definition Organic compounds that contain at least one double bond between carbon-carbon atoms. The general molecular formula for alkenes with one double bond is C n H 2n .

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