what is the n-terminal AA residue? use one-letter code for amino acid

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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what is the n-terminal AA residue? use one-letter code for amino acid

A NONAPEPTIDE that attacks and kills cancer cells has just been recently isolated from a rare fungus. Amino
acid analysis of the peptide reveals the following information below: (NOTE: when the sequence is not known,
a comma separates the amino acids)
Hydrazine
Acid Hydrolysis (6 N HCI) at 110°C
Nonapeptide
(2) Arg, Gln, (2) Tyr, Gly, Ser, Thr, and Met
2,4-dinitrofluorobenzene
DNP-Thr
Gin and
modified free
amino acids
Peptide 1
(Arg, Thr, Ser)
Cleavage with Trypsin, then chromatography
Peptide 2
(Gly, Tyr, Arg)
Met
Tripeptide
Cyanogen bromide
Dipeptide
Peptide 3
(Arg, Ser, Tyr, Thr)
Cleavage with Chymotrypsin, then chromatography
Amino acid
Peptide 4
(Gly, Arg, Tyr)
Transcribed Image Text:A NONAPEPTIDE that attacks and kills cancer cells has just been recently isolated from a rare fungus. Amino acid analysis of the peptide reveals the following information below: (NOTE: when the sequence is not known, a comma separates the amino acids) Hydrazine Acid Hydrolysis (6 N HCI) at 110°C Nonapeptide (2) Arg, Gln, (2) Tyr, Gly, Ser, Thr, and Met 2,4-dinitrofluorobenzene DNP-Thr Gin and modified free amino acids Peptide 1 (Arg, Thr, Ser) Cleavage with Trypsin, then chromatography Peptide 2 (Gly, Tyr, Arg) Met Tripeptide Cyanogen bromide Dipeptide Peptide 3 (Arg, Ser, Tyr, Thr) Cleavage with Chymotrypsin, then chromatography Amino acid Peptide 4 (Gly, Arg, Tyr)
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