What is the physiologic significance of pyruvate dehydrogenase complex?What's the biochemical basis for the management of diabetes mellitus and contrast glucose homeostasis in neonates and adults.
Q: 182. Pyruvate dehydrogenase is inhibited allosterically by- a) AMP c) NADH b) Pyruvate d) Insulin…
A: Pyruvate dehydrogenase is regulated by :- 1) Allosteric regulation - components of PDH complex -…
Q: The same E1-Ez-E3 multienzyme structure found in the pyruvate dehydro- genase and the…
A: An enzyme is a substance that acts as a catalyst in living organisms, regulating the rate of which…
Q: What is the function of the kinase associated with the pyruvate dehydrogenase complex?
A: Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into…
Q: Describe the common characteristic among the reactions catalyzed by pyruvate dehydrogenase (PDH),…
A: Pyruvate dehydrogenase (PDH), isocitrate dehydrogenase (ID), and alpha-ketoglutarate dehydrogenase…
Q: Glucagon secretion inhibits intracellular acetyl-CoA carboxylase activity through a number of…
A: The hormone glucagon is capable of regulating the activity of acetyl-CoA carboxylase. It activates…
Q: At normal to low blood glucose concentrations (l.e., roughly 110 mg/dl or less), the enzyme that is…
A: Enzymes are the type of protein that acts as biological catalysts. It speeds the rate of reaction…
Q: Which TCA component is syphoned off to increase glucose production via gluconeogenesis when glucose…
A: Glucogenesis is a metabolic pathway that results in the generation of glucose. It is an important…
Q: What is the full regulatory pathway of glycogen synthase and glycogen phosphorylase by insulin and…
A: Before going into the whole complex regulatory pathways, you need to know a few basic facts.…
Q: What is the metabolic significance of the following observations? (a) Only the liver form of…
A: The enzyme pyruvate kinase enzyme is known as an important regulatory enzyme. It takes part in…
Q: Closely related. Pyruvate dehydrogenase complex and a-ketoglutarate a-ketoglutarate dehydrogenase…
A: Enzymes are biological catalysts that help in catalyzing or speeding up biological reactions by…
Q: What are the effects of Glucose-6 Phosphate Dehydrogenase Deficiency? Explain its mechanism of…
A: Glucose 6 phosphate dehydrogenase is an important Enzyme of redox metabolism in RBC in which it…
Q: One metabolic scenario that leads to insulin resistance is the elevation of the…
A: Insulin resistance is defined as the inactivity of insulin in its target cells. The examples of…
Q: What effect does a higher ADP/ATP ratio have on isocitrate dehydrogenase activity?
A: Isocitrate dehydrogenase is an enzyme that catalyzes isocitrate's oxidative decarboxylation,…
Q: Does the allosteric regulation induced by insulin activate (or repress) phosphofructokinase-1…
A: Phosphofructose kinase 1 is a glycolytic enzyme that catalyzes the conversion of fructose…
Q: Why is pyruvate referred to as the hub of glucose oxidation?
A: Glycolysis is the oxidation of glucose to produce carbon dioxide and water. Pyruvate is the…
Q: Explain what biochemical pathway/metabolic processes are affected in insulin resistance? How does…
A: Insulin resistance is a medical condition where the cells fail to respond to the hormone insulin.…
Q: Because dichloroacetate inhibits the enzyme pyruvatedehydrogenase kinase, this compound has been…
A: Pyruvate is an important product formed during the glycolysis stage of aerobic respiration. Pyruvate…
Q: 64 An investigator is studying the mechanism of action of an insulin-sensitizing drug. The addition…
A: Introduction Insulin is a hormone produced by the gland pancreas that regulates the level of…
Q: How would the rapid accumulation of succinyl-CoA affect the rate of glucose oxidation?
A: Cellular Respiration is the oxidative process through which energy is obtained from the food. The…
Q: Glucagon secretion causes inhibition of intracellular acetyl-CoA carboxylase activity by several…
A: Glucagon, a hormone, has the ability to regulate the activity of acetyl-CoA carboxylase. It is able…
Q: 37. Which of the following enzymes catalyzes a reaction that produces NADPH needed for lipogenesis?…
A: The synthesis of fatty acids from nonlipid precursors is known as lipogenesis. It's a carbohydrate…
Q: How does exercise influence postprandial lipemia and hyperglycemia? What is a mitochondrial…
A: Exercise also aids in the reduction and alleviation of pre-existing health problems. Exercising…
Q: What are the similarities and differences between the reactions catalyzed by pyruvate dehydrogenase…
A: Introduction Respiration is a metabolic process involving the oxidation of organic compounds to form…
Q: Compare the localization of GLUT4 with that of GLUT2 and GLUT3, and explain why these localizations…
A: GLUT 4 is a type of glucose transporter. GLUT 4 transports glucose only when insulin is present.…
Q: What is the difference between Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic Syndrome (HHNS)?
A: Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic nonketotic syndrome (HHNS) are the two…
Q: Pernicious anemia. Purine biosynthesis is impaired by vitamin B12 B12 deficiency. Why? How might…
A: Pernicious anemia is a type of anemia. This is a condition in which the blood has a lower than…
Q: Draw a plausible mechanism for the oxidation of dihydrolipoamide to lipoamide by the E3 subunit…
A: A trivial term for 6,8-dithiooctanoic amide is lipoamide. Lipoamide is an efficient form of lipoic…
Q: . Briefly describe the biological rationale for cach of the following allosteric phenomena: (a)…
A: Allosteric regulation refers to the process for modulating the activity of a protein by the binding…
Q: Two of the bypass reactions of gluconeogenesis involve:
A: the two bypass reactions of gluconeogenesis are- pyruvate carboxylase convert pyruvate to…
Q: What coenzymes are required by the pyruvate dehydrogenase complex? What are their roles?
A: A coenzyme is a non-protein component of an enzyme that is required for the enzymatic reaction to…
Q: What are the coenzymes of El and E2 of pyruvate dehydrogenase complex? Explain their roles and…
A: Pyruvate dehydrogenase complex is a complex of three enzymes that converts pyruvate into acetyl-CoA…
Q: fatty acid breakdown generates a large amount of acetyl CoA. What will be the effect of fatty acid…
A: The oxidation of fatty acids and glucose provides a huge amount of ATP. The amount of energy…
Q: Correlate the importance of Citric Acid Cycle in maintaining the glucose hemeostasis.
A: The citric acid cycle involves the oxidation of acetyl CoA into CO2 and H2O. It is the final common…
Q: What is the metabolic significance of the following observations? (1) Only the liver form of…
A: Gluconeogenic Tissue : It occurs in the liver and kidneys. It supplies the needs for plasma glucose…
Q: what are the components of Pyruvate dehydrogenase Enzyme complex ?
A: Pyruvate dehydrogenase Enzyme complex is made up of three Enzymes and requires 5 coenzymes .
Q: What is the metabolic significance of the following observations? (1) Only the liver form of…
A: Glucose is catabolized to generate energy via glycolysis, the TCA cycle, and the electron transport…
Q: Which of the following enzymes possesses a catalytic mechanism extremely similar to that of the…
A: The pyruvate dehydrogenase complex resembles the alpha ketoglutarate dehydrogenase complex. The…
Q: Why most of the clinical features of the diseases Krebs Cycle inborn errors ( a- ketoglutarate…
A: Krebs cycle : This pathway plays an important role in the living cell metabolism also known as…
Q: Describe the biochemical alterations that result in type 2 diabetes.
A: In diabetes sugar or glucose level rises in the bloodstream. The hormone insulin helps glucose to…
Q: Discuss the metabolic control for HMG CoA reductase synthesis and activity
A: HMG CoA (3-hydroxy-3-methyl-glutaryl-coenzyme A) reductase, or HMGCR, is the primary rate-limiting…
Q: What are the five enzymes (including regulatory enzymes) that constitute the pyruvate dehydrogenase…
A: Introduction: The pyruvate dehydrogenase complex is a three-enzyme complex that transforms pyruvate…
Q: Is the statement "insulin inhibits beta-oxidation but stimulates fatty acid biosynthesis", cprrect?
A: Asked : If the given state is correct or not.
Q: Compare the regulation of the pyruvate dehydrogenase complex in muscle and in liver.
A: pyruvate dehydrogenase complex is a multienzyme complex that contains three enzymes that are…
Q: Predict which one of the five steps of the a-ketoglutarate dehydrogenase complex reaction is…
A: α ketoglutarate dehydrogenase complex is an enzyme complex that catalyzes the conversion of α…
Q: HBA1C control glucose for how much time ? What is the HBA1C criteria for a patient to be diagnosed…
A: Glycated hemoglobin ( HBA1C ) glycates the amino group of lysyl residues and the amino terminals…
What is the physiologic significance of pyruvate dehydrogenase complex?What's the biochemical basis for the management of diabetes mellitus and contrast glucose homeostasis in neonates and adults.
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- What is the metabolic significance of the following observations? (a) Only the liver form of pyruvate kinase is inhibited by alanine, and (b) only gluconeogenic tissues contain appreciable levels of glucose-6-phosphatase.What are the effects of Glucose-6 Phosphate Dehydrogenase Deficiency? Explain its mechanism of action.What is the full regulatory pathway of glycogen synthase and glycogen phosphorylase by insulin and the GPCR pathway?
- Why is oxaloacetate depletion from the TCA cycle important for the initiation of ketogenesis? What causes this oxaloacetate depletion? What tissue type in our body is this oxaloacetate depletion found and why is it not found in other tissues?With respect to glycogen, what is the likely fate of excess glucose 6-phosphate in muscle?Alpha-ketoglutarate dehydrogenase exhibits feedback inhibition by
- Fatty acids appear to stimulate insulin secretion to a much greater extent when glucose is also present. Why is this significant?HBA1C control glucose for how much time ? What is the HBA1C criteria for a patient to be diagnosed with diabetes mellitus ?Pyruvate dehydrogenase complex and α -ketoglutarate dehydrogenase complex are huge enzymes consisting of three discrete enzymatic activities. Which amino acids require a related enzyme complex, and what is the name of the enzyme?