What type of regulation would be expected when anaerobic metabolism is occurring in the muscle?Select all that apply.O Activation of pyruvate dehydrogenase kinaseO Increased levels of calcium to activate pyruvate dehydrogenase phosphataseO Phosphorylation of pyruvate dehydrogenaseO Inhibition of pyruvate dehydrogenase complexO Increased levels of NADH to activate citrate synthaseO Increased levels of NADH to inhibit alpha-ketogluterate dehydrogenase complexO Increased levels of acetyl CoA to activate pyruvate carboxylase for gluconeogenesis

Depending on the need of the body, the fate of intermediates of Glycolysis, gluconeogenesis, Citric…

Answered: What type of regulation would be…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...

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What type of regulation would be expected when anaerobic metabolism is occurring in the muscle? Select all that apply. 1. Activation of pyruvate dehydrogenase kinase 2. Increased levels of calcium to activate pyruvate dehydrogenase phosphatase 3. Phosphorylation of pyruvate dehydrogenase 4. Inhibition of pyruvate dehydrogenase complex 5. Increased levels of NADH to activate citrate synthase 6. Increased levels of NADH to inhibit alpha-ketogluterate dehydrogenase complex 7. Increased levels of acetyl CoA to activate pyruvate carboxylase for gluconeogenesis
Why would LDH be up- or down-regulated depending on location of cancer cells? Anaerobic cancer cells enhance rates of ATP production and rely on pyruvate to lactate conversion. LDH5 expressed can vary in favoring pyruvate for conversion to lactate (anaerobic metabolism). Aerobic compartments in newly formed fibrobasts and vessels use lactate to convert to pyruvate for oxidative phosphorylation and favor lactate conversion to pyruvate by LDH1 (aerobic metabolism). Lactate dehydrogenase is upregulated in both cancer cells and supporting stroma and vessels, thus only LDH5 is upregulated showing enhanced expression levels and thus presence at the plasma membrane to increase levels of lactate for export, LDH1 levels are always consistent. LDH1 is upregulated in response to the export of lactate by MCT1, while LDH5 is down-regulated Neither LDH1 or LDH5 are both consistently expressed, regardless of oxygen levels
Which of the following conditions is most likely to force a muscle cell to metabolize glucose anaerobically(fermentation) under normal oxygenation ? - Glyceraldehyde-3-phosphate dehydrogenase deficiency - Lactate dehydrogenase deficiency -Pyruvate kinase deficiency -Aldolase deficiency - Cytososic Glycerol-3-phosphate dehydrogenase deficiency
In the presence of high ratio of NADH/NAD in a muscle cell glucose will continue towards which metabolic pathway: a. Formation of lactic acid b. Formation of acetyl CoA c. Storage of glycogen d. Production of 34 ATP + H20 and CO2 e. Krebs cycle
The synthesis and degradation of glycogen in muscle is not a futile (ATP-hydrolyzing)cycle because:A. glycogen synthase and phosphorylase are simultaneously activatedB. cyclic AMP activates adenylate kinase. C. when glycogen synthase is inactivated, phosphorylase is simultaneously activated. D. glycogen binds Mg2+, thereby lowering the concentration of MgATP2-
Which of the listed glycolytic enzymes adds a phosphate group to ADP to produce ATP? 1.) pyruvate kinase 2.) hexokinase 3.) phosphofructokinase-1 4.) pyruvate dehydrogenase 5.) phosphexose isomerase 6.) lactate dehydrogenase
Select the correct answer: Lactate dehydrogenase (LDH) plays an essential role in an exercising muscle, especially when the level of excursion surpasses the ability of circulatory systems ability to supply adequate oxygen. What is the main reason LDH is so important to the muscle under these conditions? A)It removes excess lactic acid from the muscle to create pyruvate. B)It produces NADH for energy while converting pyruvate into lactate. C)It resupplies NAD+ to glyceraldehyde 3-phosphate dehydrogenase. D)It decreases pH thus decreasing the dissociation rate of oxygen from hemoglobin. E)It produces one mole of ATP via substrate level phosphorylation.
Insulin signals activate all of the following enzymes except: Phosphoinositide 3-kinase (PI3K) Glycogen synthase kinase 3 (GSK3) Protein kinase B (PKB; or Akt) All of the above enzymes are activated by insulin signals Citrate move in and out of mitochondria via a specific transport protein. What would happen if aninhibitor completely inhibited this transport system? Fatty acid biosynthesis would slow down Ketone body synthesis would slow down Both A and B Neither A nor B
Which of the following is the correct summary of the anaerobic breakdown of glucose in the skeletal muscle? Glucose + ADP + Pi ⟶ lactate + ATP Glucose + 2ADP + 2Pi ⟶ 2 lactate + 2ATP Glucose + 2ADP + 2Pi + 2NAD+ ⟶ 2 pyruvate + 2ATP + 2NADH + 2H+ Glucose + ADP + Pi ⟶ pyruvate + ATP Glucose + 2ADP + 2Pi ⟶ 2 pyruvate + 2ATP
Given the following question on the image identify the following:1. Total number of glucose molecules entering glycolysis2. Total number of pyruvate molecules produces at the end of glycolysis3. Total number of mitochondrial NADH produced after pyruvate is acted upon pyruvate dehydrogenase complex4.Total number of CO2 released right after the pyruvate dehydrogenase complex reactionConsider that the shuttle system is maltase-aspartate shuttle
During glycolysis, the major energy generating step involves: pyruvate kinase phosphoglycerate kinase Phosphofructokinase glyceraldehyde-3 -dehydrogenase
Which of the following statements about Pyruvate Kinase is true? a. Pyruvate kinase is activated by Fructose 1,6-bisphosphate b. Pyruvate kinase is inactivated by the Hormone Insulin c. Pyruvate kinase is activated by the hormone Glucagon d. Pyruvate Kinase is activated by Fructose 1,6-bisphosphate

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