What would be the consequence of the mismatch repair system lacking the methylating enzyme?

Q: What is the purpose of DNA methylation? Why is it ineffective in the DNA repair of spontaneous…

A: DNA methylation is the process of adding methyl groups to DNA at Nucleotide bases, so that without…

Q: What is a non replicative conservative transposon?

A: Transposons are the DNA segment that is known to move from one location to another within a genome.…

Q: How is mismatch repair different from excision repair (in terms of what type of mutation it is used…

A: In order to prevent and fix damage from mutation, all the cells have a variety of mechanisms to…

Q: With regard to the repair of double-strand breaks, what are the advantages and disadvantages of…

A: The advantages of homologous recombination repair (HRR): In this mechanism, sister chromatids are…

Q: What is meant by Genetic Information NondiscriminationAct (GINA) ?

A: Genetics can be defined as the branch of biology which is concerned with the study of genes, genetic…

Q: How can we estimate the age of a mutation?

A: Mutation is defined as sudden inheritable change that occurs in the DNA sequence. Mutation occurs…

Q: What two molecular mechanisms can result in gene conversion?Do both occur in the double-strand break…

A: A gene is a stretch of nucleotides present in the DNA. DNA or deoxyribonucleic acid is a polymer of…

Q: How do you identify copy number variations? Is copy number variation a mutation?

A: Copy number variation is defined as varying number of repeated nucleotide stretch in the genome of…

Q: Eukaryotes have repair systems that prevent mutations due to copying errors and exposure to…

A: Eukaryotic cells are complex and multicellular in nature. It consists of a true nucleus, that is the…

Q: What is the difference between a transition and a transversion? Which type of base substitution is…

A: There are two different types of mutations with DNA substitutions seen in nature.  These are of two…

Q: Which components of NER are responsible forremoving the damaged DNA?

A: Nucleotide excision repair can be defined as the DNA repair mechanism. DNA damage occurs constantly…

Q: How is methylation protective against restriction endonucleases?

A: DNA methylation is an epigenetic mechanism where a methyl group is transfered onto C5 position of…

Q: What is the Evidence for a triplet code?

A: DNA is the genetic material in most living organisms. It is the information hub of the cell that…

Q: why the repressor proteins bind with the major groove in the DNA helix?

A: DNA is a double helical structure as described by Watson and crick consisting of two loops that is…

Q: What is the difference between an Hfr chromosome using normal excision and aberrant excision?

A: High frequency recombination (Hfr) cells are the bacteria having a conjugative plasmid (Fertility…

Q: What is an interrupted mating experiment? What type of experimentalinformation can be obtained from…

A: Interrupted mating is a method used to MAP bacterial qualities by deciding the arrangement in which…

Q: What makes the deletion of a gene?

A: Deletion is a type of mutation in which a part or sequence of a chromosome that can be a single base…

Q: When the mismatch repair system detects a distortion in the DNA double helix due to a mismatch, what…

A: In the process of DNA (deoxyribonucleic acid) replication, DNA of the cell replicates itself while…

Q: Why would a mutation in a somatic cell of a multicellular organism escape detection?

A: Mutations that likely occurred in a somatic cell are not supposed to be transferred to its next…

Q: Is duplication a mutation?

A: Mutations are defined as the permanent change in the DNA’s base sequence. An agent that causes…

Q: What is cotransduction? What determines the likelihood that two genes will be cotransduced?

A: We have to have the knowledge of genetics to answer this question.

Q: What role does DNA methylation play in mismatch repair?

A: DNA methylation is a biochemical process, in which a methyl group is added to the nucleotides of…

Q: During mismatch repair, why is it necessary to distinguish betweenthe template strand and the newly…

A: Mismatch repair (MMR) is a significant system of repairing deoxyribonucleic acid (DNA) errors in all…

Q: How does e.coli and human cells distinguish between the old and new strands for mismatch repair?

A: DNA (deoxyribonucleic acid) is the genetic material in all living systems. DNA replication is a…

Q: In mismatch repair, how does the cell "know" which strand is the correct strand and which strand is…

A: During DNA synthesis,  DNA polymerases keep checking their work and keep fixing the majority of…

Q: Question 50 The presence of non-Watson base pair

A: A DNA repair mechanism is a group of processes that helps to correct the faulty or damaged DNA. This…

Q: What is methylated cap?

A: Post-transcriptional modification includes a set of biological process occurring in eukaryotes by…

Q: Why would a mutation in a somatic cell of a multicellular organism not necessarily result in a…

A: Eukaryotic organisms have two types of cells: germ cells which produces gametes and somatic cells…

Q: With regard to the repair of double-strand breaks, what are the advantages and disadvantages of…

A: Double strand breaks is a mechanism to repair any break in the double stranded DNA molecule. The…

Q: How do alkylating agents, nitrous acid, and hydroxylamine produce mutations?

A: The mutagens are the agents that are responsible for causing the genetic mutations. It is classified…

Q: What are the factor of expressed sequence tag?

A: Expressed sequence tags are small stretches of DNA sequences that are typically 100 to 800…

Q: What are the chances of occurence of amorphic mutation?

A: Mutations are defined as the change in the sequence of DNA of an organism due to any environmental…

Q: xplain how mismatch repair fixes incorrectly matched base pairs.

A: During DNA synthesis, most DNA polymerases use a process is called proofreading to double-check…

Q: Why do some chromosomes display a higher incidence of amplification/deletion compared to others?

A: When the nucleotides sequences in the genome of an organism are altered or changed due to mistakes…

Q: What is microsatellite polymorphism?

A: Polymorphism:   It is set place in population when two members or at least two or more members of…

Q: Explain how mismatch repair fixes incorrectly matched base pairs.

A: During DNA synthesis, most DNA polymerases use a process is called proofreading to double-check…

Q: How do we know that DNA repair mechanisms detect and correct the majority of spontaneous and induced…

A: DNA can be defined as the deoxyribonucleic acid, which is the molecule that contains the genetic…

Q: If homologous and site-specific recombination could not occur,what would be the harmful and the…

A: DNA is the genetic material in most living organisms. It is the information hub of the cell that…

Q: • Inversions alter the order, but not the number, of geneson a __________

A: The number and the structure of the chromosomes are maintained as such during the meiosis, however,…

Q: Which of the following mechanisms is involved in double-strand DNA repair? a. Homology-dependent…

A: Homology directed repair (HDR) is a system in cells to fix double strand DNA lesions. The most…

Q: Why are mutations in the INK4 locus so dangerous?

A: INK4 is a cyclin-dependent kinase inhibitor family (CKIs). Inhibitors of CDK4 and CDK6 are…

Q: What is the rationale for developing anti-cancer agents that inhibit telomerase?

A: We all know that ,cancer is an abnormal growth and uncontrolled division of cells that spreads in…

Q: What is single-nucleotide polymorphisms (SNPs) ?

A:

Q: explain the process of homology-dependent repair?

A: All living organisms are made up of cell. It can be either unicellular organism or multicellular…

Q: What is the difference between DNA and protein methylation?

A: Methylation is a type of epigenetic modification which regulates gene expression.

Q: DNA methylation in mismatch repair

A: REPAIR PATHWAYS:- Both in Prokaryotes and Eukaryotes, there is a repair enzyme system to deal with…