When glycolytic flux exceeds the mitochondrial flux, the majority of pyruvate is converted to pyruvate glucose-1-phosphate lactate acetyl-CoA
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When glycolytic flux exceeds the mitochondrial flux, the majority of pyruvate is converted to
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pyruvate |
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glucose-1-phosphate |
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lactate |
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acetyl-CoA |
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- The co-enzyme that helps in the removal of carbon dioxide from pyruvate during the PDH mechanism is Pyruvate oxidative decarboxylase CoA NAD+ Thiamine PyrophosphateDuring glycolysis, the major energy generating step involves: pyruvate kinase phosphoglycerate kinase Phosphofructokinase glyceraldehyde-3 -dehydrogenaseIn the liver, what is the fate of pyruvate under conditions of the Cori Cycle? Acetyl CoA to fuel TCA Conversion to oxaloacetate primarily for glucose biosynthesis Conversion to lactate Conversion to oxaloacetate primarily for amino acid biosynthesis
- Which of the following events does not occur during pyruvate processing (pyruvate oxidation)? One carbon atom of each pyruvate is oxidized to carbon dioxide. NAD+ coenzyme is reduced to NADH. The remaining two carbon atoms of pyruvate (acetyl unit) reacts with coenzyme A to produce acetyl CoA. FAD coenzyme receives two hydrogen atoms to produce FADH2.What is the first cofactor to accept electrons from pyruvate in the Pyruvate dehydrogenase complex? Thymine pyroposphate lipoyllysine FAD NAD⁺The first enzyme in the Krebs cycle is theA.citrate synthaseB.pyruvate dehydrogenaseC. α- ketoglutarate dehydrogenase D.aconitase
- Describe the role played by each enzyme, cofactor, andcoenzyme of the pyruvate dehydrogenase complexElevated levels of acetyl-CoA will act as an effector for which of the following enzymes? more than one can be correct Pyruvate carboxylase. Pyruvate kinase Pyruvate dehydrogenase. Citrate synthase a-Ketoglutarate dehydrogenase.Most defects in pyruvate dehydrogenase complex are due to mutations in ______, so supplements with ______ are given. E2 and TPP E1 and lipoamide E3 and NAD+ E2 and lipoamide E1 and TPP
- Which of the following is true concerning the function of lipoic acid in pyruvate metabolism? a. transfer of acetyl groups b. pyruvate decarboxylation c. conversion of pyruvate to lactate d. oxidation of FADH2 to yield NADHIf the TCA cycle is over-stimulated, too much of _____ will be produced. acetyl-CoA glucose pyruvate carbon dioxide oxygenBefore pyruvate enters the citric acid cycle, it is decarboxylated, oxidized, and combined with coenzyme A, forming acetyl CoA, carbon dioxide, and one molecule of (a) NADH (b) FADH2 (c) ATP (d) ADP (e) C6H12O6