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- When p53 is activated, a cell cannot progress: A. throught M-phase B. from G2 into M phase C. From G1 into S phase D. Throught S-phase E. from s-pahse into G2Which of the following statements correctly describes p53? Which of the following statements correctly describes p53? A) It is a membrane receptor that binds to growth factors such as EGF. B) p53 binds to pre-replication complexes promoting the transition from G1 to S phase. C) p53 activates cyclin-CDK complexes. D) Activation of p53 leads to inhibition of the cyclin-CDK complexes. E) Cell division stops until p53 binds to DNA and repairs the damage.Which protein is a positive regulator that phosphorylates other proteins when activated? a. p53 b. retinoblastoma protein (Rb) c. cyclin d. cyclin-dependent kinase (Cdk)
- In a few sentences, describe how p53 guards the genome. Include at least two specific ways that p53 guards the genome. In a few more sentences, describe the structure and function of the p53 protein. Structure: what domains are present in the p53 protein? Do p53 work as a single protein or as part of a complex? Function: what do the different domains do? How can p53 do so many different things?In a healthy cell, which of the following proteins will be activated in order to suppress cell division if the cell is not ready or should not divide? Select one: a. p53 b. cdk c. cyclin d. seperase e. mitogenIs the CDK present in Mitotic checkpoint?
- Define about Several types of cellular stress events bring about rapidincreases in the nuclear levels of activated p53 protein ?Q. Cyclins and CDK(inase) complexes regulate the cell cycle. Which of the following statements is true? A. Cyclins activate CDKs which remove phosphates from other proteins. B. Cyclins activate CDKs which add phosphates to other proteins. C. CDKs activate cyclins which remove phosphates from other proteins. D. CDKs activate cyclins which add phosphates to other proteins.List the regulatory mechanisms that might be lost in a cell producing faulty p53.