Why is it advantageous for p53 to be activated by factors such as ER stress, light, and hypoxia (low oxygen concentration)?

Q: What two substrates does the protein kinase MAPKKK have? MAPKK and Ras-GTP АТР and MAРКК МАРКК and…

A: MAPKKK is involved in the protein cascade during cell signalling.

Q: After DNA damage (e.g. caused by X-ray exposure) in eukaryotic cells, the cell cycle can be arrested…

A: The protein cyclin and CDK (cyclin-dependent protein kinase) act together to drive the process of…

Q: Name four downstream effects of p53 activation.

A: Gene expression is usually accomplished through mRNA transcription and protein synthesis. p53 is a…

Q: What is the role of Rho factors in transcription, how it performs its function?

A: The process that occurs as a part of the Central Dogma of life and is involved in the formation of a…

Q: Activation of p53 during cellular stress will generally Select one: o a. Increase transcription of…

A: P553 is a tumor suppressor gene.

Q: Loss of p53 function occurs in the majority of human tumors. Name two ways in which loss of p53…

A: A tumor is considered an abnormal growth of tissues in the body. The tumor can be cancerous, if it…

Q: is the p53 protein an activator or a repressor? How do you know?

A: p53 protein is protein which is coded by Tp53 gene which is also known by the name Gaurdian of the…

Q: Mutations that inactivate p53 have a recessive phenotype, whereas mutations affecting Ras are…

A: P53 is a tumor protein, which codes for the protein that regulates the cell cycle and suppresses…

Q: in a fat cell what is the result of activation of genes by PPAR gamma/activator proteins binding?…

A: Peroxisome proliferator - activated receptor(PPAR) gamma is a  nuclear receptor of subfamily 1,group…

Q: Define about Several types of cellular stress events bring about rapidincreases in the nuclear…

A: The p53 is also known as the guardian of the genome. It is a tumor suppressor gene. The function of…

Q: What is the difference in how mediator works with activation vs. repression of transcription?

A: Transcription refers to the mechanism in which the genetic information in DNA is transferred by RNA…

Q: GAP protien mutation from Arg 789 to alanine constituvely activate the MAPK pathway by preventing…

A: Cell growth and cell division are essential for the development of an organism. A cell before any…

Q: During certain stages of cell growth, the requirement for certain gene products may require gene…

A: Gene amplification is the rise in amount of a specific portion of the genome differentially, in…

Q: How does p53 halt cell cycle progression when DNA damage is identified? p53 enhances expression of…

A: p53 protein is a transcription factor that regulates the expression of several genes which are…

Q: p53 can trigger apoptosis if certain cell-cycle events fail. How does this regulatory outcome…

A: Apoptosis is the programmed cell death. Apoptosis is one of the important events in development that…

Q: Describe the ATM-p53 repair pathway in normal cells and cancerous cells

A: Apoptosis is a genetically controlled mechanism of cell death, which is important for the…

Q: How is the signal generated by binding of TGF-β to cell-surface receptors transmitted to the…

A: TGF-β is a cytokine of the transforming growth factor family of signaling molecules with multiple…

Q: Why is it advantageous for p53 to be activated by factorssuch as ER stress, UV light, and hypoxia…

A: The p53 is known as tumor protein formed from the TP53 gene. The protein acts as a tumor suppressor…

Q: When p53 is activated, a cell cannot progress:   A. throught M-phase B. from G2 into M phase C. From…

A: The p53 protein acts as a tumor suppressor, which means that it regulates cell division by keeping…

Q: In chapter 8 we read that in tumor cells Rb protein is hyperphosphorylated. In response to that,…

A: p53 suppresses the cell proliferation mediated by the Rb-E2F pathway. Phosphorylation of Rb by…

Q: How does each of these small GTP-binding proteins contribute to the regulation of cell migration?

A: GTP bonding protein also known as G protein.G protein is present in eukaryotic and classifieds into…

Q: protein do cyclin – dependent kinases bind to become active?

A: Cyclin-dependent kinases are protein kinases that play a major role in cell cycle control. They…

Q: Suggest a mechanism by which ARF leads to p53 build-up.

A: p53 protein gets activated when there is a damage in  DNA sequence which can be induced by any other…

Q: // Which CDK and cyclin does p53 ultimately target in DNA damaged conditions? O CDK1/cyclin E O…

A: CDK phosphorylate soecific target proteins. They required cyclin to be activate. CDK-cyclin…

Q: The destruction of the various cyclins is commonly used to inactivate the Cdk/cyclin complexes. Why…

A: Cancer or tumor growth occurs when the cell cycle regulation mechanisms fail to stop the division of…

Q: How does the activity of human p53 get regulated through the interaction of the transactivation…

A: p53 is basically a transcription factor that helps in suppressing the growth of the tumor. This…

Q: T7-MDM2 Myc-RYBP p53-(His-Ub), MDM2 p53 Myc-RYBP B-Actin QUESTION 12 In the RYBP case study paper,…

A: *Ring1 and YY1 binding protein (RYBP) belongs to polycomb group proteins that implicated in…

Q: What means genes are delivered directly to somatic cells?

A: Gene therapy is a collection of methods that allows correction of a gene defect that has been…

Q: How do studies of brain development in knockout mice support the statement that apoptosis is a…

A: Apotopsis is a process of programmed cell death. It is a process in which the cell division is…

Q: What is the effect of having fluctuating cyclin levels throughout the cell cycle, while the levels…

A: Cell cycle  It is a series of events in which cell duplicate it's organelles and divide.

Q: Describe the effects of the mutation causing the p21 promoter to no longer bind p53 on cell…

A: p53 is a tumor suppressor gene but if p53 gets mutated then this protein is not able to bind to the…

Q: What is a signal-transduction pathway? Why are mutations in components of signal-transduction…

A: Cells are the basic structural, functional, and biological units of all living organisms. It is the…

Q: A p53 knockout mouse in which both copies of p53 are defectivehas been produced by researchers. This…

A: p53 is a gene that makes protein call tumor protein and it acts as tumor suppresor.  It is found…

Q: Given that CDKS are "kinases", how do they activate or inactivate other proteins? Why are cyclins…

A: Period between two mitotic division is called as the cell cycle. Cell cycle is the event taking…

Q: You are analyzing the activity of the protein p53 in two different cell types. You notice that p53…

A: The function of a protein is primarily related to its structure if the composition of protein is…

Q: The p53 protein regulates the expression of BAX and Bcl2 to keep division at normal rate. Explain…

A: The p53 gene codes for p53 protein which regulates the expression of BAX and Bcl2 to keep cell…

Q: How are tissue-specific transcription factors regulated? Identify three different ways

A: Transcription factors are the type of proteins that bind to the specific sites in the DNA and…

Q: Which of the following can lead to p53 stabilization and activation? O Hypoxia

A: P53 is a tumour suppressor gene that plays an important role in controlling cell division and cell…

Q: What would be the effect on transcription if a mutation occurred in the gene that encodes GAL3, so…

A: Transcription is a very significant level of gene expression control in eukaryotes and needs various…

Q: degrading p53 protein in the cel

A:

Q: List the regulatory mechanisms that might be lost in a cell producing faulty p53.

A: The cell cycle is the series of events that lead to the formation of new cells from the parent…

Q: How do mitochondrial proteins interact with IAPs to prevent inhibition of apoptosis?

A: Multicellular organisms experience apoptosis, which is a type of programmed cell death. Cell death…

Q: what are the normal funtions of the p53 gene

A: p53 gene is also called as tumour suppressor gene or Tp53 gene produces the protein called tumour…

Q: How do RER and SER differ from one another in terms of structure and function? List the processes in…

A: A cell is the basic key of life that is capable of performing all the functions of life and also…

Q: Why are the proteins called p53 and Ras studied so much these days?

A: P53 and Ras, both proteins are involved in the cancer mechanism. Cancer is a condition in which the…

Q: Which of the following must occur for programmed cell death (apoptosis): 1. p53 must be stabilized…

A: Apoptosis is called as the programmed death of the cell which is controlled genetically. The protein…

Q: In tumor cells Rb protein is hyperphosphorylated. In response to that, will p53 level increase or…

A: Rb protein is a very powerful tumor suppressor protein it checks the cell cycle and when it's levels…

Q: Because DNA is found in the nucleus, transcription is a nuclear-localized process. Ribosomes…

A: Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins…