Which of the following are assumptions of the Hardy Weinberg equilibrium model? Mark all the correct assumptions. No mutation Gene flow No selection Natural selection
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Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
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- Some people can taste the bitter compound phenylthiocarbamide while others cannot. This trait isgoverned by a single autosomal gene; the allele fortasting is completely dominant with respect to the allele for nontasting. Among 1707 Hawaiians tested forthe ability to taste, 1326 tasters were found. Assumingthat the population is at Hardy-Weinberg equilibriumfor this gene and that mating is purely random:a. What are the allele frequencies for the tasting alleleT [= (p)] and for the nontasting allele t [= (q)]?b. What are the genotype frequencies in the population?c. Of all the matings in the population, what proportion will be between two nontasters?d. Of all the matings in the population, what proportion will be between a taster and a nontaster?e. Of all the matings in the population, what proportion will be between a taster male and a nontasterfemale?f. What proportion of all of the progeny produced byall matings between a taster male and a nontasterfemale will be nontasters?g. Of all…A large, random mating population is started with thefollowing proportion of individuals for the indicatedblood types:0.5 MM0.2 MN0.3 NNThis blood type gene is autosomal, and the M and Nalleles are codominant.a. Is this population at Hardy-Weinberg equilibrium?b. What will be the allele and genotype frequenciesafter one generation under the conditions assumedfor Hardy-Weinberg equilibrium?c. What will be the allele and genotype frequenciesafter two generations under the conditions assumedfor Hardy-Weinberg equilibrium?Using the HardyWeinberg Law in Human Genetics Suppose you are monitoring the allelic and genotypic frequencies of the MN blood group locus (see Question 2 for a description of the MN blood group) in a small human population. You find that for 1-year-old children, the genotypic frequencies are MM = 0.25, MN = 0.5, and NN = 0.25, whereas the genotypic frequencies for adults are MM = 0.3, MN = 0.4, and NN = 0.3. a. Compute the M and N allele frequencies for 1-year-olds and adults. b. Are the allele frequencies in equilibrium in this population? c. Are the genotypic frequencies in equilibrium?
- Using the HardyWeinberg Law in Human Genetics In a given population, the frequencies of the four phenotypic classes of the ABO blood groups are found to be A = 0.33, B = 0.33, AB = 0.18, and i = 0.16. What is the frequency of the i allele?Height in humans is controlled by the additive action of genes and the action of environmental factors. For the purposes of this problem, assume that height is controlled by four genesA, B, C, and Dand that there are no environmental effects. Assume further that additive alleles contribute two units of height and partially additive alleles contribute one unit of height. a. Given these assumptions, can two individuals of moderate height produce offspring that are much taller and shorter than either parent? If so, how can this happen? b. Can someone of minimum height and someone of intermediate height have children taller than the parent of intermediate height? Why or why not?Color blindness in humans is caused by an X-linked recessive allele. Ten percent of the males of a large andrandomly mating population are color-blind. A representative group of 1000 people from this population migrates to a South Pacific island, where there are already1000 inhabitants and where 30 percent of the males arecolor-blind. Assuming that Hardy–Weinberg equilibrium applies throughout (in the two original populationsbefore the migration and in the mixed population immediately after the migration), what fraction of malesand females can be expected to be color-blind in the generation immediately after the arrival of the migrants?
- In a randomly mating laboratory population of Drosophila, 4 percent of the flies have black bodies (encodedby the autosomal recessive b), and 96 percent havebrown bodies (the wild type, encoded by B). If this population is assumed to be in Hardy–Weinberg equilibrium, what are the allele frequencies of B and b and thegenotypic frequencies of B/B and B/b?Let’s suppose that weight in a species of mammal is polygenic, andeach gene exists as a heavy and light allele. If the allele frequenciesin the population are equal for both types of alleles (i.e., 50%heavy alleles and 50% light alleles), what percentage of individualswill be homozygous for the light alleles in all of the genesaffecting this trait, if the trait was determined by the followingnumber of genes?A. TwoB. ThreeC. FourIn mice, black fur (W) is dominant over white fur (w). In an ideal mouse population exhibiting Hardy–Weinberg equilibrium, 177 mice out of 236 have white fur. Calculate the number of mice that are heterozygous dominant for the fur colour gene in the population.
- A danger in computing heritability values from studiesinvolving genetically related individuals is the possibility that theseindividuals share more similar environments than do unrelatedindividuals. In the experiment shown in Figure 24.8, which dataare the most compelling evidence that ridge count is not causedby genetically related individuals sharing common environments?ExplainA certain form of congenital glaucoma is caused by an autosomalrecessive allele. Assume that the mutation rate is 10-5 and that peoplewith this condition produce, on the average, only about 80% of theoffspring produced by people who do not have glaucoma.a. At equilibrium between mutation and selection, what will the frequencyof the gene for congenital glaucoma be?b. What will the frequency of the disease be in a randomly matingpopulation that is at equilibrium?Three linked loci A, B, C (each with two alleles as in Question 2) in a random mating population havethe gametic frequencies as shown below. Calculate the linkage disequilibium D/Dmax between eachpair of loci. Explain why the results seem paradoxical. [based on Hartl 3rd ed. Q1.15 – try on yourown before checking the answer, and show your calculations for D and Dmax]Gamete ABC ABc AbC Abc aBC aBc abC abcFrequency 0.25 0 0.25 0 0 0.25 0 0.25 respectively