Which of the following are examples of post- translational modification (PTM)? (select two answers) Genomic DNA is methylated by a DNA methyltransferase, altering the binding of transcription factors. Glycogen phosphorylase becomes active when phosphorylated by glycogen phosphorylase kinase. Glucose is phosphorylated by hexokinase as the first step in glycolysis. Ras is active when bound to GTP, and inactive when bound to GDP. Caspase 3 is activated when cleaved by capsase 9.

Which of the following are examples of post- translational modification (PTM)? (select two answers) Genomic DNA is methylated by a DNA methyltransferase, altering the binding of transcription factors. Glycogen phosphorylase becomes active when phosphorylated by glycogen phosphorylase kinase. Glucose is phosphorylated by hexokinase as the first step in glycolysis. Ras is active when bound to GTP, and inactive when bound to GDP. Caspase 3 is activated when cleaved by capsase 9.

Name: Which of the following are examples of post-translational modificatio
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Description: Which of the following are examples of post-translational modification (PTM)? (select twoanswers)Genomic DNA is methylated by a DNAmethyltransferase, altering the binding oftranscription factors.Glycogen phosphorylase becomes active whenphosphorylat

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter9: Gene Expression And Gene Regulation

Section: Chapter Questions

Problem 18QP: The following is a portion of a protein: met-trp-tyr-arg-gly-pro-thr-Various mutant forms of this...

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Number the following steps of protein synthesis in order in which they occur, starting with 1 and ending with 9. a. ____ the stop codon is reached, and the polypeptide is released b.____ the small ribosomal subunit finds the start codon, and the large ribosomal subunit joins. c.____ the end of the gene is reached, and the pre-mRNA is released and then edited. d. ____ The transcription factor bonds the promoter. e. ____ the protein is folded and modified to become functional. f. ____ RNA polymerase builds the mRNA transcript. g. ____ mRNA and initiator tRNA bind the small ribosomal subunit. h. ____ new tRNAs are brought into the A site successively, and the peptide chain of the tRNA in the P site is joined to the amino acid of the tRNA in the A site. i. ____ mRNA exits the nucleus via a nuclear pore.
Many blood clotting proteins undergo a post-translational modification in which specific glutamic acid residues (Glu) in the protein are converted to gamma-carboxyglutamic acid residues (Gla). See reaction scheme below. An example is the blood clotting protein Factor IX, which has 12 Glu in its N-terminus converted to Gla. This modification gives Factor IX the ability to bind calcium and phospholipid membranes. Bacteria do not have the enzyme required to convert Glu to Gla and therefore Factor IX proteins expressed in bacteria would not have the proper modifications. How might you engineer the translational apparatus of a bacterial cell line so that it produces Factor IX with Gla in the appropriate positions. How would you ensure that only the 12 Glu in Factor IX that are normally converted to Gla and not just all Glu (Limit 5-6 senetnces)?
The following is a portion of a protein: met-trp-tyr-arg-gly-pro-thr-Various mutant forms of this protein have been recovered. Using the normal and mutant sequences, determine the DNA and mRNA sequences that code for this portion of the protein, and explain each of the mutations. a. met-trp- b. met-cys-ile-val-val-leu-gln- c. met-trp-tyr-arg-ser-pro-thr- d. met-trp-tyr-arg-gly-ala-val-ile-ser-pro-thr-
Design a transcriptional circuit that regulates the expression of β-galactosidase in a eukaryoticcell, such that the enzyme is produced in the presence of lactose and repressed in the absenceof lactose. Use at least one of the following elements: histone acetyltransferase, histonedeacetylase, chromatin remodeling complex
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