Which of the following are the correct types of chromosomal mutation as shown from Figure 1.4? * Original sequence Original sequence 2 trameshift Original sequence Original sequence 3 frameshift Figure O 1. Inversion 2. Deletion 3. Translocation 4. Insertion 1. Inversion 2. Insertion 3. Deletion 4. Translocation 1. Insertion 2. Deletion 3. Inversion 4. Translocation O 1. Deletion 2. Translocation 3. Insertion 4. Inversion
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- Why is karyotyping significant in understanding chromosomal abnormalities? Short essay only thanks please the main answergiven the photos below, what general type of chromosomal mutation did colchicine induce ? 1st photo- untreated 2nd photo - colchicine-treatedMatch the genetic disorder to the descriptions below: Edward Syndrome Jacob Syndrome Patau Syndrome Turner Syndrome Prader-Willi Syndrome Down Syndrome (trisomy) Klinefelter Syndrome Cri du Chat 18-Q Deletion Syndrome Translocation Down Syndrome ________ deletion of part of the P arm of chromosome 5. Improperly developed larynx causes cat-like cry until age 2. IQ is under 20. ________ deletion of Q arm of chromosome 15. Affected individuals have a small head, are retarded, and exhibit bizarre behavior. ________ deletion of Q arm of chromosome 18. Affected individuals have thirteen pairs of ribs (normal is 12 pairs) and IQ under 30. ________ extra 21st chromosome attaches to chromosome 14. Affected individ- uals exhibit epicanthic folds of eyelids, simian crease in palms, and retardation. ________ trisomy 18. Affected individuals…
- Using the data below please identify the following: Identify which of the siblings in generation II has a recombinant chromosome. Determine which of his/her children is at risk of developing adenomatous polyposis based on the new data. Table 2 RFLP data for a family suffering from APC syndrome. III1 III2 III3 II1 II2 III4 III5 III6 I1 I2 II3 II4 III7 II5 II6 III8 III9 III10 II7 II8 III11 III12 III13 II9 II10 A A A A A A A A A A A A B B B B B B B B B B B B B B B B B B B C C C C C C C C D D D D D D DWhat are the similarities a chromosomal mutation and point mutation?PLEASE ANSWER THE FOLLOWING LETTERS: a,b,c, and d Examine the pedigree of the McGraw family shown below. Certain individuals in this family are affected by a brain condition that makes them more susceptible to vertigo. As a genetic counselor, you interview the family and draw DNA samples. You discover that the condition is caused by a mutation that changes the sequence 5’GCATTC3’ to 5’GAATTC3’ introducing an EcoRI cut site. You decide to amplify a 1200bp fragment from the DNA that spans this mutation and then digest it with EcoRI. You run the results on a gel next to a marker that shows bands at 2000bp, 1200bp, 900bp, 800bp, and 400bp. Some individuals from the pedigree are identified on the gel.
- Draw a hairpin structure like that shown in Figure 18.5 for the repeated sequence found in fragile-X syndrome (see Table 18.1).. A diploid strain of yeast was made by mating a haploidstrain with a genotype w−, x−, y−, and z− with a haploidstrain of opposite mating type that is wild type for thesefour genes. The diploid strain was phenotypically wildtype. Four different X-ray-induced diploid mutantswith the following phenotypes were produced fromthis diploid yeast strain. Assume a single new mutation is present in each strain.Strain 1 w− x+ y− z+Strain 2 w+ x− y− z−Strain 3 w− x+ y− z−Strain 4 w− x+ y+ z+When these mutant diploid strains of yeast go throughmeiosis, each ascus is found to contain only two viablehaploid spores.a. What kind of mutations were induced by X-rays tomake the listed diploid strains?b. Why did two spores in each ascus die?c. Are any of the genes w, x, y, or z located on thesame chromosome?d. Give the order of the genes that are found on thesame chromosomeAltered chromosome structure can drastically affect an individual organism’s phenotype. However, some types of chromosomal rearrangements are more likely to be harmful than others. Categorize the following types of rearrangements from MOST LIKELY to be harmful to LEAST LIKELY to be harmful. A. reciprocal translocation, deletion, translocation B. deletion, translocation, inversion C. inversion, translocation, reciprocal translocation D. translocation, inversion, duplication
- A normal chromosome A B C D * E F G H I J K has mutated toA B C F E * D G H I J K J K.This is an example of a _________________ chromosomal mutation. ( * denotes the centromere) Group of answer choices Pericentric inversion of DEF and tandem duplication of JK. Pericentric inversion of DEF and displaced duplication of JK Paracentic inversion of DEF and displaced duplication of JK. Paracentric inversion of DEF and tandem duplication of JK.Lay out the genetics of Nicholas’s case, including where the mutationoccurred, what exact nucleotide defect was present, why this was aserious type of defect, and why he was so affected by the mutationbut his mother was not.You have identified a SNP marker that in one largefamily shows no recombination with the locus causinga rare hereditary autosomal dominant disease.Furthermore, you discover that all afflicted individuals in the family have a G base at this SNP on theirmutant chromosomes, while all wild-type chromosomes have a T base at this SNP. You would like tothink that you have discovered the disease locus andthe causative mutation but realize you need to consider other possibilities.a. What is another possible interpretation of the results?b. How would you go about obtaining additional genetic information that could support or eliminateyour hypothesis that the base-pair difference is responsible for the disease?