Which of the following is required to transport fatty acids across the inner mitochondrial membrane? (A) Acyl carrier protein (B) Albumin (C) Carnitine (D) Chylomicrons (E) Creatinine (F) Lecithin-cholesterol acyltransferase
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- Why does ATP production require an intact mitochondrial membrane?The inner mitochondrial membrane exhibits all of the fundamental characteristics of a typical cell membrane, but it also has several unique characteristics that are closely associated with its role in oxidative phosphorylation. What are these unique characteristics? How does each contribute to the function of the inner membrane?What are two advantages of the components of the electron transport chain being embedded in the inner mitochondrial membrane?
- How is the Inner Mitochondrial Membrane (IMM) different from the Outer Mitochondrial Membrane (OMM) ?The fatty acid side chains of the phospholipids in the inner mitochondrial membrane exhibit a large proportion of multiple unsaturations. As a result, will the membrane be hydrophobic or hydrophilic? Also will it be more fluid or more rigid? How do these characteristics help explain the observation that the inner membrane is impermeable to ions such as Mg2+ and Cl–? Hint: what moves these ions through the membrane?How does mitochondrial structure contribute to aerobic metabolism, particularly to the integration of the citric acid cycle and electron transport?
- An important function of the inner mitochondrial membrane is to provide a selectively permeable barrier to the movement of water soluble molecules and thus to generate different chemical environments on either side of the mem- brane. However, many of the substrates and products of oxidative phosphorylation are water soluble and must cross the inner membrane. How does this transport occur?A new weight loss drug, Super Fat Melter, is introduced on the market but then quickly recalled after a few patients die. As it turns out, the pill makes the lipid bilayer of the inner mitochondrial membrane leaky to H+. What impact does this have on ATP production? Explain, with reference to the type of phosphorylation affected.Could the inner mitochondrial membrane carry out its functions in the coupling of electron transport and ATP synthesis if its lipid bilayer were readily permeable to hydrogen ions (protons)?