Which of the following statements is correct about the development of T cells? O After many cell generations, some of the CD8+ T cells differentiate into at least six functional phenotypes. - T cells differentiate into progenitor cells destined to become (1) natural T regulatory (Treg) cells, (2) natural killer T (NKT) cells, (3) gamma/delta T cells, and (4) alpha/beta T cells. Activation by its specific antigen causes a T helper cell (TH) cell to mature into a cytotoxic T lymphocyte (CTL) that functions to destroy host cells that have been infected by intracellular pathogens, such as a virus, or have altered MHC surface proteins. T cells originate from CD34+ stem cells in the bone marrow, where they also mature.

Which of the following statements is correct about the development of T cells? O After many cell generations, some of the CD8+ T cells differentiate into at least six functional phenotypes. - T cells differentiate into progenitor cells destined to become (1) natural T regulatory (Treg) cells, (2) natural killer T (NKT) cells, (3) gamma/delta T cells, and (4) alpha/beta T cells. Activation by its specific antigen causes a T helper cell (TH) cell to mature into a cytotoxic T lymphocyte (CTL) that functions to destroy host cells that have been infected by intracellular pathogens, such as a virus, or have altered MHC surface proteins. T cells originate from CD34+ stem cells in the bone marrow, where they also mature.

Anatomy & Physiology

1st Edition

ISBN:9781938168130

Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Chapter21: The Lymphatic And Immune System

Section: Chapter Questions

Problem 18RQ: Which type of T cell is most effective against viruses? Th1 Th2 cytotoxic T cells regulatory T cells

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Similar questions

All of the following are true in reference to T-cell priming except _____. a. it occurs in primary lymphoid organs b. it transforms naive T cells into differentiated effector T cells c. it is the first stage of a primary adaptive immune response d. it requires interaction between naive T cells and antigen-presenting cells e. it takes place in many locations including, but not limited to, lymph nodes, Peyer’s patches, and the tonsils.
Explain why each choice (a-d) is correct or incorrect. T cells are differentiated into two groups based on their glycoproteins CD4 or CD8. Which of the following is true of CD4 T cells? a. They become cytotoxic T cells. b. The become antigen presenting cells. c. They become T helper cells. d. They become plasma cells.
To avoid the potential for activating self-reactive T cells that might cause autoimmunity, naive T cell activation has stringent requirements for co-stimulatory signals in addition to the engagement of T-cell receptors with peptide: MHC complexes. Yet this requirement is abandoned once T cells have differentiated into effector cells. Name two effector T cell functions that would fail if effector T cells also required T-cell receptor signals plus co-stimulatory signals through CD28 to elicit their effector responses.
All of the following are examples of how tumors or the microenvironment in which they develop suppress immune responses except _____. a. induction of T-cell anergy b. peptide splicing of self proteins c. cleavage of MIC glycoproteins from tumor-cell surfaces d. TGF-β-induced recruitment of regulatory T cells e. release of TGF-β and IL-10 by regulatory T cells.
During activation, there is a secondary exchange of signals between the presenting cell & activated T cells is called ________ -_______________________________. This prevents inappropriate activation of T cells. The important cytokine we discussed that is secreted by T helper cells is ____________________________________.
Name the 4 types of T cells and give the function of each one. (note: Suppressor T cell is also known as Regulatory T cell)
All of the following are characteristic of regulatory T cells except a. they express CD25 b. they facilitate the proliferation of naive T cells interacting with the same antigen-presenting cell c. they express CD4 d. they express the transcriptional repressor FoxP3 e. they express MHC class II-restricted T-cell receptors specific for self antigen.
During the early developmental stages of α:β T cells in the thymus, there are two key checkpoints that must be satisfied to permit the progression of T-cell development. Explain what occurs at each checkpoint.
CD1-restricted α:β T cells respond to lipid antigens of mycobacterial pathogens using all except which of the following? a. CD1a b. CD1b c. CD1c d. CD1d.
Which of the following describes the developmental pathway for T cells? a. thymus → bone marrow → spleen b. thymus → bone marrow → thymus c. bone marrow → thymus → lymph nodes d. lymph nodes → thymus → spleen e. bone marrow → lymph nodes → thymus.
Some immune system cells like B lymphocytes and T lymphocytes must first be "trained" in either the bone marrow or thymus because they can do their jobs. Which of the following best describes the purpose of this "training" during their maturation? to selectively remove any lymphocytes that show immunity against our own cells and our own antigens in our body to expose these cells to all of the potential pathogens and their antigens they may encounter in the future to activate them so that they differentiate into plasma and memory cells and begin producing antibodies to make sure that each lymphocyte is capable of recognizing a large number of different pathogen antigens to initiate a secondary and stronger immune response after encountering an invading pathogen
Which of the following pairs is mismatched? a. plasma cell: mediation of phagocytosis and killing of microorganisms in the plasma b. megakaryocyte: formation of platelets c. dendritic cell: activation of adaptive immune responses d. natural killer cell: develops from a common lymphoid progenitor e. neutrophil: formation of pus f. regulatory T cell: inhibition of T-cell activity.