Which of the following types of mutations would be advantageous to a cancer cell (select all that apply)? A. An inactivating mutation in a tumor suppressor gene B. Methylation of the promoter of a tumor suppressor gene C. An inactivating mutation in an oncogene D. Mutation that inactivated DNA repair gene E. An inactivating mutation in an oncogene

Which of the following types of mutations would be advantageous to a cancer cell (select all that apply)? A. An inactivating mutation in a tumor suppressor gene B. Methylation of the promoter of a tumor suppressor gene C. An inactivating mutation in an oncogene D. Mutation that inactivated DNA repair gene E. An inactivating mutation in an oncogene

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter17: Developmental Genetics

Section: Chapter Questions

Problem 8TYU: Which of the following statements about cancer is false? (a) oncogenes arise from mutations in...

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Which of the following statements about cancer is false? (a) oncogenes arise from mutations in proto-oncogenes (b) tumor suppressor genes normally interact with growth-inhibiting factors to block cell division (c) more than 120 cancer-driving genes have been discovered (d) oncogenes were first discovered in mouse models for cancer (e) the development of cancer is usually a multistep process involving both oncogenes and mutated tumor suppressor genes
Which of the following statements correctly describes a characteristic of tumor-suppressor gene? a) they are frequently overexpressed in cancerous cells. b) they are cancer-causing genes introduced into cells by viruses. c) they encode proteins that help prevent uncontrolled cell growth. d) they often encode proteins that stimulate the cell cycle.
Most forms of cancer involvea. the activation of a single oncogene.b. the inactivation of a single tumor-suppressor gene.c. the activation of multiple oncogenes.d. the activation of multiple oncogenes and the inactivation ofmultiple tumor-suppressor genes.
Which of the following is true of tumor suppressor genes? Group of answer choices a) If this gene is overactive, it becomes an oncogene b) If one of the alleles is mutated, there is usually little effect. Two inactivating mutations are usually required for loss of function (recessive mutation). c) If one copy is lost, the gene no longer functions (dominant mutation) d) Tumor suppressors genes usually cause mitosis or cell growth e) Tumor suppressor genes decrease apoptosis
Which of the following accurately compares tumor suppressor genes and proto-oncogenes? A. Both tumor suppressor and proto-oncogenes prevent the spread of cancer by targeting and destroying existing cancer cells. B. A person who has both tumor suppressor and proto-oncogenes will always develop cancer. C. Proto-oncogenes code for growth factors, while tumor suppressor genes inhibit cell division of damaged cells. D. When a proto-oncogene mutates, it becomes a tumor suppressor gene.
Which of the following mutations is MOST likely to cause cancer? A) a mutation that causes a cyclin gene to be expressed at all times during the cell cycle B) a mutation that causes an oncogene to be turned off so that no protein is made C) a mutation that causes a Cdk gene to be turned off so that no protein is made D) a mutation that causes a tumor suppressor gene to be over-expressed
Normal (nonmutant) tumor-suppressor genes often functiona. as negative regulators of cell division.b. in the maintenance of genome integrity.c. in the stimulation of cell division.d. as both a and b.
Which of the following best describes a gene that codes for a tumor-suppressor protein? a. One that helps to prevent progression through the cell cycle. b. One that helps prevent apoptosis. c. One that codes for a DNA repair enzyme. d. One that supports part of a growth factor signaling pathway.
Cells in a tumor contain mutated copies of a particular gene that promotes tumor growth. Gene therapy can be used to introduce a normal copy of this gene into the tumor cells. Would you expect this therapy to be effective if the mutated gene were an oncogene? A tumor-suppressor gene? Explain your reasoning.
Which of the following factors contributes to angiogenesis as a result of a tumor growth? Select all that apply: a. Increasing tumor's access to oxygen and nutrients b. Increasing tumor's ability for growth, invasion, and metastasis c. Increasing expression of proto-oncogenes for cancer cells d. Increasing expression of tumor-suppressor genes for cancer cells
Which of the following is not a tumor suppressor gene? a.RET b.RB c.BRCA1 d.BRCA2
In some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an oncogene or a tumor-suppressor gene? Explain your reasoning

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	A.	An inactivating mutation in a tumor suppressor gene
	B.	Methylation of the promoter of a tumor suppressor gene
	C.	An inactivating mutation in an oncogene
	D.	Mutation that inactivated DNA repair gene
	E.	An inactivating mutation in an oncogene