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Which of the Pedigree diagrams below is most likely to show a family with Galactosemia?
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- Analysis of Autosomal Recessive and Dominant Traits Describe the phenotype and primary gene or protein defect of the X-linked recessive disease muscular dystrophy.Classical hemophilia is a sex-linked disease caused by a recessive gene on the X chromosome. (Hemophilia refers to diseases that cause delays in blood clotting.) If a woman who is acarrierof classical hemophilia has children with a normal male, give the ratios of the possible offspring with respect to classical hemophilia. Be sure to state both the genotypes and the phenotypes of each offspring. For genotypes, use X for a normal X chromosome, Xh for an X chromosome with the hemophilia gene, and Y for a normal Y chromosome. For phenotypes, if the offspring is female, be sure to state if homozygous normal, a carrier, or has the disease. If the offspring is a male, be sure to state if normal or has the disease.Explain the following terms in your own wordsa. Genotypeb. Phenotypec. Alleled. Dominante. Recessivef. Heterozygousg. Homozygou
- Suppose that a female with the mutation (i.e., a heterozygous female) mates with a healthy male (the male’s genotype is homozygous recessive). What is the probability that their child has an increased susceptibility to breast cancer?please show punnett square alsoA man is brachydactylous (very short fingers; rare autosomal dominant), and his wife is not. Both can taste thechemical phenylthiocarbamide (autosomal dominant;common allele), but their mothers could not.a. Give the genotypes of the couple.If the genes assort independently and the couple hasfour children, what is the probability ofb. all of them being brachydactylous?c. none being brachydactylous?d. all of them being tasters?e. all of them being nontasters?f. all of them being brachydactylous tasters?g. none being brachydactylous tasters?h. at least one being a brachydactylous taster?Shown above is a family pedigree tree in which family members afflictedwith the disease Haemophilia are shown with filled-in squares (male) or circles (females). A couple is trying to determine the likelihood of passingon the disease to their future children (represented by the ? symbolabove) because the hemophilia runs in the woman’s family. Turner syndrome is a disease in which an individual is bornwith only a single X chromosome. Suppose the woman in thecouple is a carrier for hemophilia and has a child with Turnersyndrome. Would this child have the disease?
- Huntington’s disease, is an incurable neurodegenerative genetic disorder that affectsmuscle coordination and some cognitive functions, typically becoming noticeable inmiddle age. It results from an autosomal dominant gene (H) and there are no carriers ofthe disease. Two parents with Huntington’s disease have an affected child. What is theprobability that their next child will be an unaffected girl if they are not double-dominant?Duchenne muscular dystrophy (DMD) is caused bya recessive mutant allele of an X-linked gene calleddystrophin. Rarely, females have disease symptomsas severe as those in males hemizygous for therecessive allele. These females are heterozygous forX-autosome reciprocal translocations where the Xchromosome breakage occurred in the middle of thedystrophin gene, breaking it into two pieces.a. If it is equally likely for X chromosome inactivation to spread from either of the X chromosomeinactivation centers (XICs; see Fig. 12.15) in thecells of this patient, what proportion of her cellswould you expect to have normal function of thedystrophin gene?ABO Blood TypeThe following pedigree shows the incidence of ABO blood types in a family. dentify the genotypes of the following individuals: Individual Genotype II-1 II-2 II-4 II-5 III-2 III-3
- A person has the genotype AabbCCDdEEFfGgHH for 8 genes. State how many genes are homozygous dominant, how many genes are heterozygous, and how many genes are recessive.Tell me whether it is autosomal reccessive inheritance,autosomal domiant inheritance,sex-linked reccessive inheritance, sex-linked dominay inheritance or y-linked inheritance based on information given.(With Pedigree Anlaysis Breakdown)Match the chromosome disorder to its descriptionin the key. Jacobs syndrome a. female with undeveloped ovaries and uterus, unable to undergopuberty, normal intelligence, can live normally with hormonereplacementb. XXY male, can inherit more than two X chromosomesc. male or female, mentally impaired, short stature, flat face, stubbyfingers, large tongue, simian palm creased. XXX or XXXX femalee. caused by nondisjunction during spermatogenesis