Why is it that not all the angles between C-N can freely rotate?
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Why is it that not all the angles between C-N can freely rotate?
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- the peptide sequence in single letter code is T N C H P, please hand draw a peptide diagram satisfied the following conditions * Show the position of all ‘heavy’ atoms with the appropriate letter (C, N, O, S etc.) and indicate the number of attached hydrogen atoms (no skeletal structures allowed). * Show all double bonds and/or partial double bonds. * Draw all ionisable groups as their most highly populated state at pH 7. * Make the peptide bond between the fourth residue and proline the cis isomer. * Show all other peptide bonds as trans. * Show the alpha carbon of every residue as tetrahedral and the L isomer. * All trigonal planar groups must be shown explicitly with appropriate geometry. 2. Give the name and three letter code for each amino acid in the peptide. 3. At pH 7, approximately what charge would be on your peptide? Explain your answer. 4. Can your peptide form intra/interchain disulfide bonds? Explain why/why not. 5. Will your peptide absorb UV (either strongly, weakly…The amino acid sequence of three peptide fragments are shown below. Peptide 1: QAMGRAGDLKYLGLHSV Peptide 2: ALMALFMVMALVLVSVLFIA Peptide 3: MVEDLLKQIARYLISE (a) Circle all of the charged residues in peptide 1 (assume pH =7.0). Box all of the aromatic residues in peptide 2. Underline all of the nonpolar residues in peptide 3. (b) Determine the net charge of the predominant form of each of the peptides at pH 4.5 and pH 11.5. Assume the ionizable groups have the pKa values listen in Table 2.1 of your text. (c) Which of these peptides would be most likely to be found as an alpha helix in a soluble (cytoplasmic) protein? Which would be most likely to be found as an alpha helix in a transmembrane protein? Which would be least likely to form an alpha helix of any kind?There is parts A-D for the picture provided. A) A peptide has the sequence, Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 1? Choices: -5 -4 -3 -2 -1 0 +1 +2 +3 +4 +5 B) A peptide has the sequence Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 5? Choices: -5 -4 -3 -2 -1 0 +1 +2 +3 +4 +5 C) Same Peptide sequence, What is the net charge at pH8.5, (N-terminus is pronated) Choices: -5 -4 -3 -2 -1 0 +1 +2 +3 +4 +5 D) A peptide has the sequence, Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 13? Choices: -5 -4 -3 -2 -1 0 +1 +2 +3 +4 +5 Thank You!
- What is a zwitterion? Support answer with illustration In naming an amino acid, how many indicate whether it is in the D or L configuration? Support answer with illustration How are amino acids linked together in a protein molecule? Write the general structure of the tripeptide lys-phe-meth. Show their peptide Bonds. (with illustration; label the amino acids)Draw a peptide containing ELPT amino acids at pH 7 and label the phi and psi bonds. What is the isometric point of the peptide?A peptide containing 18 amino acid residues in its sequence was partially hydrolyzed and peptides A–D were detected in the resulting mixture. Draw the sequence of the original peptide.A Phe-Gly-AlaB Ser-Ser-Ser-Trp-Phe-Gly-AlaC Phe-Phe-Met-Ala-Ala-Pro-Trp-CysD Met-Ala-Ala-Pro-Trp-Cys-Leu-Ile-Leu-Ser-Ser
- Draw the structure and give the name of the pentapeptide GRAND. Encircle all peptide bonds as wellConsider the peptide EAHIVR. Write out the sequence of the peptide from N to C in three letter code. Draw the complete structure of the peptide including all peptide bonds and side chains at pH 8.0. Calculate the pI of this peptide. Calculate the net charge of this peptide at pH 2, pH 7, and pH 11.N - Leucine - Arginine - Proline - Aspartic acid - Methionine - C write the structure classify the type of peptide number of peptide bonds IUPAC name 3 - and 1 letter abbrevation. Solve for pI Determine the charge @ pH = 1, 3, 5, 10 & 13
- A peptide has the sequence Glu–His–Trp–Ser–Gly–Leu–Arg–Pro–GlyGlu–His–Trp–Ser–Gly–Leu–Arg–Pro–Gly The p?apKa values for the peptide’s side chains, terminal amino groups, and carboxyl groups are provided in the table. Amino acid Amino pKa Carboxyl pKa Side‑chain pKa glutamate 9.609.60 2.342.34 4.254.25 histidine 9.179.17 1.821.82 6.006.00 tryptophan 9.399.39 2.382.38 serine 9.159.15 2.212.21 glycine 9.609.60 2.342.34 leucine 9.609.60 2.362.36 arginine 9.049.04 2.172.17 12.4812.48 proline 10.9610.96 1.991.99 Calculate the net charge of the molecule at pH 3.During the formation of the peptide bond which of the following takes place? Select one: a. Hydroxyl group is lost from its carboxyl group of one amino acid and a hydrogen atom is lost from its amino group of another amino acid b. Hydrogen atom is lost from its carboxyl group of one amino acid and a hydroxyl group is lost from its amino group of another amino acid c. Hydroxyl group is lost from its carboxyl group of one amino acid and a hydroxyl group is lost from its amino group of another amino acid d. Hydrogen atom is lost from its carboxyl group of one amino acid and a hydrogen atom is lost from its amino group of another amino acid Clear my choicea peptide has the sequence: Asp-His-Tyr-Asn. What is the net charge on this molecule at pH 7.2?