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- The complete coronavirus genome sequence from the first known patient infected with SARS-CoV-2 was published on January 10th 2020, just a short time after the patient had been hospitalized in China with respiratory symptoms. They did this so quickly using nanopore sequencing. Scientists compared the genome sequence from the new coronavirus (SARS-CoV-2) with the genome sequences from several other coronaviruses and they did identify a sequence unique to the SARS-CoV-2 strain. This unique sequence was in the N gene of the viral genome. What protein is made from the N gene of the virus?Answer the following and inlcude the references SARS-CoV-2, the virus that causes CoVid-19, belongs to the Coronaviridae family. Viruses under this family have a genome made of single-stranded positive-sense RNA. Is this similar to the viral genome of HIV? If so, do you think that – in theory – they would have similar replication cycles? Do you think that ART combinations/options might help in suppressing the viral replication of SARS-CoV-2? Expound.Every year, the United States and the world suffer a serious outbreak of emerging, re emerging or endemic disease. Using documented and reliable sources on the internet, find information about COVID-19 and its history. Please also list the souces used. 1: Vaccine development What are vaccines and how do they work? What attenuated virus vaccines are, who developed the vaccine (if one exists) and in what year, what strain was within the first vaccine. current vaccines available, and what strains they cover, and what current protocols are for vaccination in the US and in other countries Discuss current US state policies on vaccination requirements. If no vaccine is available, describe any current R&D or clinical trials in effect right now. 2: CDC and outbreak information On the CDC website and other sources to identify: - When widespread vaccination began and when it effectively eradicated the disease here (also discuss what that means) if applicable. 2. Outline past/ present…
- Influenza virus is an RNA virus with a segmented genome whereas SARS-Cov-2, the cause of COVID19 disease, is an RNA virus with an unsegmented genome. Which of the following reasonsexplain why influenza viruses are more likely to cause a global pandemie? Select ALL that apply.a).Both influenza viruses and SARS-COV-2 undergo antigenic driftb).Influenza viral strains can exchange genomes in the same host cell.c).SARS-COV-2 can undergo antigenic shift.d).SARS-COV-2 viral strains can exchange genomes in the same host celle).Influenza viruses can undergo antigenic shift.answer doesn't have to be long i just need an explanation, thank you! The whole world right now is concerned (or they should be) about the appearance of new variants of SARS-CoV-2. Among other things, these variant viruses have mutations that change the amino acid sequence of the spike protein on the virus surface. While this is concerning, I would like to propose that there is a limit to how far these mutations can change the spike protein. Why can't there be an endless number of new mutations of this viral protein? How would these amino acid changes affect how the virus works?The advantage of a ____________ sense genome is that RDRP doesn’t need to be carried in the virion for the virus to successfully infect a new cell. The advantage of a ________________ sense genome is that it gives the virus greater ability to differentially regulate its genes
- Can you please pick the right answer in each parentheses? The spike protein of SARS-CoV-2 is a carbohydrate-modified protein that ["bind the RNA genome of the virus", "", "is on the surface of the viral particle", ""] and plays a role in both ["replication of the viral genome", "recognition of host cell"] and ["packaging of viral genome for export", "fusion of viral envelope with host cell plasma membrane"] . Importantly, earlier work on spike proteins from other corona viruses showed that this molecule ["remarkable resistance to immune response", "shows remarkable conformational changes"] and only one of these served as a good antigen for vaccine development. A critical discovery in advancing the development of our current vaccines was determining what changes in the amino acid sequence would ["block degradation of the spike protein", "stabilize the conformation of the protein found on the viral particle"]. This…Transmission studies suggest that there are at least three (3) different variants of the SARS-CoV-2 virus circulating in Latin America and the Caribbean. Discuss a recombinant DNA technology strategy that could be used to verify this claim.Compare and contrast the genetic material of SARS-COV-2 and Influenza Type A Virus.
- “The SARS Coronavirus Type 2 (SARS-CoV-2) is known to cause respiratory tract infections and has been isolated from several bodily fluids. Although there is still no concrete evidence of an animal reservoir, the World Health Organization has prematurely classified the Coronavirus disease (COVID-19), caused by SARS-CoV-2, as a zoonotic disease”.2.1 In your own view, discuss the possible route of transmission of SARS-CoV-2 from an animalsource to humansTopic is SARS-CoV-2 Describe how mutations or genetic variation contributed to either: the evolution of your pathogen (or) the host’s chance of resisting the pathogen or surviving the infection If applicable, you can also discuss how genetic variation or mutation have made it difficult (or easy) to treat infection caused by your pathogen.Coronaviruses (CoV) are a family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). Coronavirus disease (COVID-19) is a new strain, not previously identified in humans, that emerged to a pandemic. Describe one way a preexisting virus can become an emerging virus.