You are given two data sets that provide counts of F1 and F2 offspring with given genders and disease phenotypes. The data are generated from an initial parental cross. One parent displays the disease phenotype and one displays the wild-type (WT) phenotype.The WT parent always has a homozygous genotype. There are three possible modes of inheritance that underlie the generation of the data. All are monogenic. They are:
You are given two data sets that provide counts of F1 and F2 offspring with given genders and disease
The data are generated from an initial parental cross. One parent displays the disease phenotype and one displays the wild-type (WT) phenotype.The WT parent always has a homozygous genotype.
There are three possible modes of inheritance that underlie the generation of the data. All are monogenic. They are:
(i) Autosomal Recessive.
(ii) Homozygous Lethal Dominant.
(iii) Autosomal Dominant.
One's phenotype is determined by their genotype at the disease locus and the mode of inheritance, as we have seen with the Punnett Square.
In this file you are provided with the true mode of inheritance.
Your assignment is to perform a chi-square goodness of fit test on each of two F2 data sets, and make a decision, based on your statistical analyses as to which F2 data set provides greater evidence for indicating the correct mode of inheritance.
Evidence is measured in the following ways: the p-value is greater than 0.05, so we do not reject the null hypothesis, and the p-value is closer to 1.
A few things of which to be mindful.
- In the parental generation, the WT parent always has a homozygous genotype.
- For the autosomal dominant moi, the disease is always homozygous for the disease allele.
- For the autosomal dominant, homozygous lethal any person with the disease phenotype is heterozygous for their genotype.
- The mode of inheritance is the same for both data sets, and so is the parental cross.
DATA SET 01
The number of offspring in F1 and F2 generations: 510
The true mode of inheritance is autosomal dominant.
Parental cross: Father with disease phenotype, Mother with wild-type phenotype.
F1 COUNTS FOR DATA SET 01
Phenotype
Gender. Disease Wild-Type
Male 237 0
Female 273 0
F2 COUNTS FOR DATA SET 01
Phenotype
Gender Disease Wild-Type
Male 185 73
Female 183 69
DATA SET 02
The number of offspring in F1 and F2 generations: 899
F1 COUNTS FOR DATA SET 02
Phenotype
Gender Disease Wild-Type
Male 424 0
Female 475 0
F2 COUNTS FOR DATA SET 02
Phenotype
Gender Disease Wild-Type
Male 349 112
Female 323 115
F2 COUNTS FOR DATA SET 01
| Gender | Phenotype | Observed counts (O) |
Expected Proportions |
Expected Counts (E) |
(O-E) | (O-E)^2/E |
| Male | WT | 73 | ||||
| Male | Disease | 185 | ||||
| Female | WT | 69 | ||||
| Female | Disease | 183 | ||||
| Total | 510 | |||||
| DegFrdm | ||||||
| P-value |
F2 COUNTS FOR DATA SET 02
| Gender | Phenotype | Observed counts (O) |
Expected Proportions |
Expected Counts (E) |
(O-E) | (O-E)^2/E |
| Male | WT | 112 | ||||
| Male | Disease | 349 | ||||
| Female | WT | 115 | ||||
| Female | Disease | 323 | ||||
| Total | 899 | |||||
| DegFrdm | ||||||
| P-value |
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