When a person exercises, muscle contractions produce lactic acid. Moderate increases in lactic acid can be handled by the blood buffers without decreasing the pH of blood. However, excessive amounts of lactic acid can overload the blood buffer system, resulting in a lowering of the blood pH. A condition called acidosis is diagnosed if the blood pH falls to 7.35 or lower. Assume the primary blood buffer system is the carbonate buffer system described in Exercise 45. Calculate what happens to the [H2CO3]/[HCO3 2] ratio in blood when the pH decreases from 7.40 to 7.35.

Principles of Modern Chemistry
8th Edition
ISBN:9781305079113
Author:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Publisher:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Chapter15: Acid–base Equilibria
Section: Chapter Questions
Problem 103AP
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When a person exercises, muscle contractions produce lactic

acid. Moderate increases in lactic acid can be handled by the

blood buffers without decreasing the pH of blood. However,

excessive amounts of lactic acid can overload the blood buffer

system, resulting in a lowering of the blood pH. A condition

called acidosis is diagnosed if the blood pH falls to 7.35 or

lower. Assume the primary blood buffer system is the carbonate

buffer system described in Exercise 45. Calculate what

happens to the [H2CO3]/[HCO3

2] ratio in blood when the pH

decreases from 7.40 to 7.35.

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