At elevated temperatures, nucleic acids become denatured; that is, they unwind into single-stranded DNA. Account for the observation that the higher the G-C content of a nucleic acid, the higher the temperature required for its thermal denaturation.

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At elevated temperatures, nucleic acids become denatured; that is, they unwind into single-stranded DNA. Account for the observation that the higher the G-C content of a nucleic acid, the higher the temperature required for its thermal denaturation.

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