Huntingtin

Huntington's Disease Background Huntington's disease is inherited as an autosomal dominant disease that gives rise to progressive, elective (localized) neural cell death associated with choleric movements (uncontrollable movements of the arms, legs, and face) and dementia. It is one of the more common inherited brain disorders. About 25,000 Americans have it and another 60,000 or so will carry the defective gene and will develop the disorder as they age. Physical deterioration occurs over a period

genetic sequence is known to cause a particular disease, the nucleic strand can be synthesized to bind to the messenger RNA (mRNA) produced to the gene to inactivate and thus silence the gene. Upon the expansion of the CAG tract in the huntingtin gene (HTT), a toxic huntingtin protein (HTT) forms with an elongated polyglutamine tract. Wild-type HTT is quite critical during the during early

a defect in chromosome four that triggers the production of defective a defective protein called “huntingtin”, which kill off brain cells affecting reasoning and motor skills. Unfortunately the defective chromosome four is dominant and can appear even if one parent is not a carrier of Huntington’s Disease. In a person free from the disease, the activity of chromosome four and it’s normal huntingtin is

segment is repeated 10 to 35 times within the gene. In people with Huntington disease, the CAG segment is repeated 36 to more than 120 times. An increase in the size of the CAG segment leads to the production of an abnormally long version of the huntingtin protein. The elongated protein is cut into smaller, toxic fragments that bind together and accumulate in neurons, disrupting the normal functions of these cells. The dysfunction and eventual death of neurons in certain areas of the brain underlie

Overview Huntington’s Disease is a dominant, autosomal, neurodegenerative disease that results from excess CAG repeats on the human chromosome 4. These CAG repeats code for a protein named Huntingtin, and patients of Huntington's Disease have a mutated form of it. Symptoms begin to appear in one’s middle ages and continue to progress over a span of about 20 years. It leads to loss of mental ability and muscle coordination, as well as increasing one’s vulnerability to depression. Those who develop

combination CAG is repeated too many times. In people without HD this CAG is repeated 5 to 35 times. In people who are affected by HD, CAG is repeated over and over again between 36 and 121 times. The CAG combination codes for a protein called huntingtin. Why the increase number of CAG causes HD is still unknown. It is thought that too much of the HD protein makes them obtain some new, abnormal property. This is true in two

Huntington’s disease is a degenerative neurological disorder affecting movement, cognition, and emotional state (Schoenstadt). There are two forms of Huntington’s disease (Sheth). The most common is adult-onset Huntington’s disease, with persons usually developing symptoms in their middle 30s and 40s (Sheth). There is an early onset form of Huntington’s disease, beginning in childhood or adolescence, and makes up a small percentage of the Huntington’s population (Sheth). Huntington’s disease is a

Huntington’s Disease is a brain disorder affecting movement, cognition, and emotions (Schoenstadt). It is a genetic disorder generally affecting people in their middle 30s and 40s (Sheth). Worldwide, Huntington’s disease (affects between 3-7 per 100,000 people of European ancestry (Schoenstadt). In the United States alone, 1 in every 30,000 people has Huntington’s disease (Genetic Learning Center). Huntington’s Disease is a multi-faceted disease, with a complex inheritance pattern and a wide range

Genetic diseases are conditions caused by abnormalities in the genetic material contained within our cells. Huntington’s Disease. Huntington’s disease is an inherited disorder of the central nervous system, and the degeneration of nerve cells in the brain, which causes the brain to deteriorate. The symptoms of Huntington’s disease are physical (however it mainly affects movement rather than body image) , behavioural (mainly mood and personality), and cognitive (especially the way you think

chance that you will develop it at some point in your life. Huntington’s disease is caused by a defect in the dominate gene called huntingtin. This defect is caused by a part of DNA called CAG repeat. Normally the huntingtin gene is repeated about ten to twenty-eight times, and plays a major role in brain development. When a person has Huntington’s disease the huntingtin disease repeats anywhere from 36 to 120 times. When the gene repeats this much the elongated proteins separate into smaller pieces