Huntingtin

Huntington 's Disease Our bodies and the functions of our body parts work in cohesion. Some systems include but not limited too cardiovascular, urinary, respiratory, digestive, endocrine, reproductive, and most importantly the nervous system. The central nervous system consists of the brain and the spinal cord and the peripheral nervous system consist of all the nerves that branch off of the brain and spinal cord. With those systems we have the sensory division and the motor division also stemming

Discuss the role of poly-glutamine (poly-Q) in Huntington’s disease (HD) Introduction: The gene IT15 (Interesting Transcript 15) (Zheng et al, 2010) codes for the protein Huntingtin (htt) which contains exon1 (XN1). XN1 is the nucleotide sequence that is within Htt protein. Polyglutamine (poly-Q) is a short protein fragment of more than two amino acids called a peptide that is within XN1. It is the consequences of the expansion in poly-Q that causes Huntington’s Disease (HD). HD is the condition

Shaw and McKay, best explains the experiences of Michael Lopez. First off, Michael Lopez grew up in Huntingtin Park, CA, which many would consider part of the South Central area of Los Angeles. This area is notoriously crime ridden, and Michael Lopez was most likely influenced by the gang culture that he was surrounded by. According to Social Disorganization theory, these areas, such as Huntingtin Park, are called transitional zones. Usually these areas are

that over 30,000 Americans have Huntington’s and over 200,000 people are currently at risk for developing the disease later in life (“What is Huntington’s Disease”). Huntington’s disease is caused by a mutation in the gene for a protein called Huntingtin. The genetic mutation results in the building blocks of DNA (cytosine, adenine, and guanine) to be replicated many more times than in an average individual. As a result, Huntington’s disease breaks down brain cells, or neurons, specifically located

is Huntington’s disease, which causes involuntary spasms and contractions and a decline of coordination and cognitive ability (Online Mendelian Inheritance in Man [OMIM], 2014). These symptoms occur as a result of a trinucleotide repeat in the huntingtin gene on chromosome 4p16.3, also known as the HTT gene. The disease is autosomal dominant, with the completeness of its

copy of this gene yields the protein huntingtin. However, when the defective gene is bigger than usual, it yields huntingtin in a larger quantity. The etiology becomes fickle when reasons concerning why this defective protein damages the portion of the brain that administers movement. Scientists reveal that the reasoning is due to a miniscule protein called Rhes, which is found in the brain portion that governs movement. Overall, the mutant protein huntingtin causes Huntington’s disease and the defective

great importance as well. Huntington’s disease is a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain and eventually causes death. It is caused by a mutation in a gene that is responsible for producing the huntingtin protein. Over a period of time, physical and mental abilities gradually deteriorate, and there is currently

Huntington’s Disease Imagine not remembering the names of your family members, having difficulty swallowing, not being able to control your movements. Imagine being trapped in a body that is turning against you, slowly deteriorating around you and you are helpless to stop it. This is the very real and terrifying reality for those with Huntington’s disease. “Many describe the symptoms of HD as having ALS, Parkinson’s and Alzheimer’s – simultaneously.” This disease isn’t picky, it devastates the families

The discovery that double-stranded RNA can efficiently silence gene expression (RNA interference, RNAi) was made by Andrew Fire and Craig Mello in 1998 in the worm C. elegans (Fire et al., 1998). It has since been hailed as one of the most important innovations in modern molecular medicine and accordingly, the pair were awarded the Nobel Prize in Medicine and Physiology in 2006. This discovery opened up a whole new field of biological research which has impacted all aspects of medicine including

are areas in the brain that are more affected than others. The area that is affected the most is the basal ganglia. It is a group of structures that controls movement and behavior. The disease is displayed due to a mutation in the gene, which is huntingtin. While it is uncertain as to what the gene does, it plays an