on vascular depression, but the mechanism remains unknown. In this study, we found that 2 weeks of treatment with quetiapine prior to bilateral carotid artery occlusion and reperfusion, in an animal model of vascular depression, resulted in reduced myelin breakdown and oligodendrocyte loss compared to placebo-treated mice on post-operative day (POD) 7. For late stage of recovery (POD40), quetiapine treatment resulted in enhanced oligodendrocyte maturation relative to placebo. The results suggest that
of schizophrenia. Oligodendrocytes are the myelin-producing cells in the central nervous system. To test the myelination dysfunction hypothesis of schizophrenia, possible myelination dysfunction was evaluated in a phencyclidine (PCP)-induced neurodevelopmental model of schizophrenia. On postnatal day
a relative lack of stem cells, and growth-inhibitory proteins located in the extracellular matrix and on cell surfaces. Myelin-associated inhibitors of neurite outgrowth, found on oligodendrocytes, represent a significant obstacle to the process of cortical reorganization that occurs during recovery from infarction. Recent research has identified the mechanisms by which these inhibitors act in the setting of stroke, paving the
¬¬¬¬¬¬¬MMR is an immunization vaccine that protects against measles, mumps and Rubella. The first dose is given to babies between the ages of 12-13 months and the second dose (which is given as a booster) to 1 and 5 year olds. It was first developed by Maurice Hilleman while at Merk& Company Inc. The MMR vaccine contains weakened versions of live measles, mumps and rubella viruses. The vaccine works by triggering the immune system to produce antibodies against measles, mumps and rubella. Children
system of the body attacks the myelin sheath. Myelin is a fatty substance rich in proteins that surrounds, insulates, and protects the nerve as well as helps to speed up nerve transmissions. Neurons are the basic working part of the brain that transmit messages to other nerves in the body. Every neuron in the central nervous system has a cell body and an axon. An axon is the extension of the cell body that carries messages and it is here that myelin plays its role. Myelin is wrapped around the axon for
mechanism after spinal cord injury. There was no considerable disparity in the 10-Gy and the 20-Gy group from this experiment. In our results myelin showed first a decrease, and then an increase following spinal cord injury in rats. This outcome indicated that the spinal cord injury and repair coexisted, by being injured first and then repairing it. In addition, the myelin count significantly decreased in the irradiation group at week 14 after spinal cord injury, which showed that ionizing radiation also
Recently, it has been demonstrated by DNA microarray analysis that myelin gene regulatory factor (MRF) expression is specific to terminally differentiated oligodendrocytes (Cahoy et al., 2008; Heiman et al., 2008). Importantly, knockdown of MRF in oligodendrocytes by RNA interference downregulates expression of the majority CNS myelin genes (Emery et al., 2009). In contrast, overexpression of MRF in in vitro cultured OPCs can promote myelin gene expression. Oligodendrocyte lineage-specific MRF knockout
system (CNS)” (Pasquier, 2014, 537). Specifically, it is a chronic auto-immune disease that attacks the central nervous system. Furthermore, the person’s own immune system does not recognize the neurons and attacks the myelin, and the nerve fibers it covers and protects. The myelin then creates scar tissue which causes damage and keeps the nerve impulses in the neuron from being able to travel to the brain or the spinal cord. If this occurs, bodily functions become difficult or impossible because
structurally and by controlling the passage of substances into the cells. Together these cells form an insulating layer around the neurons called the myelin sheath. This myelin sheath is similar to the rubber which coats the wires of your telephone. Yet in a person with Multiple Sclerosis, the immune system mistakenly identifies some component of myelin as a foreign agent, or antigen. This elicits an auto-immune response in which the body attacks and slowly destroys this protective covering and replaces
The Brilliant Club Final Assignment Nathan Bell Introduction This essay is going to list and compare adult and adolescent behaviour, characteristics and try to analyse how certain adolescent characteristics change into adulthood. It will look at what characteristics change and what don’t, look up the information to do with the question and rewrite the information without changing the meaning and make sure it will have the source links at the bottom of the essay. It will show images of the brain at