Osteoclast

that originate from mesenchymal stem cell lineage. Osteoblasts produce bone matrix which they later mineralized to form bone. During the process of bone formation, matured osteoblasts usually get trapped in the bone matrix and become osteocytes. Osteoclasts on the other hand, are the main bone resorbing cells; they resorb bone producing proteolytic enzyme and acid. In response

directed to the production of calcium and the directing of calcium into the blood where it is transported to provide for numerous functions in various other systems of the body. When calcium levels begin to decrease again, the cycle begins anew when osteoclasts break down the bone matrix to dissolve calcium

matrix secretion (osteoblast) and breaks down bone (osteoclast). Both cells are a vital factor in bone growth, healing, and remodeling. Other important cells include osteogenic cells, osteocytes, and bone lining cells. Osteogenic cells mitotically divide and later form into osteoblasts. Osteocytes are aged bone cells that no longer divide, but do perform as stress receptors and respond to mechanical weight and impact by communicating with osteoclasts and osteoblasts to promote bone remolding. Finally

Endochondrial ossification is the term used for the development of new bone. Bone growth and remodelling takes place on a continual basis, ossification lengthens and thickens bone and therefore the process of ossification is used throughout life as well as during the period after bone fracture. Endochondral ossification, this type of bone development involves cartilage models, which are then replaced with bony tissue. This takes place at the embryonic stages; 8 weeks into development, condroblast

roles of osteoblasts and osteoclasts. During our adolescent years our bones are evolving to become protracted and broader. Therefore, formation is occurring until we have reached our peak bone mass. The peak bone mass is usually reached by the age of 30; therefore, as we age formation decelerates. Essentially, exercising is an ethical verdict, especially during our matured years. One of the key elements of regulating skeletal growth is the Osteoclasts. The Osteoclasts are responsible for initiating

My particular bone model, representing that of the femur, beared the ability to withstand and support the weight of a standard textbook. Depicted on the outermost portion is that of the periosteum, the element in which provides protection for the remaining sections of the bone. Additionally, I was able to incorporate a representation of compact bone into the model; the unforgiving nature of this tissue greatly aided in supporting the substantial weight. A key component within my model was that of

after birth. 2. What are the roles of osteoclasts in bone formation? Osteoclasts are large cells that function to reabsorb, or to digest bone tissue. They digest bone tissue from the inner sides of bones thus enlarging the inner bone cavity so that the bone does not become overly thick and heavy. 3. How does osteoblast assist when recovering from a fractured bone? When a bone breaks osteoblast lay down the mineral bone matter (calcium salts) and osteoclasts removes excess bone debris (smooth out

disease that affects bone growth, causing bones to become deformed and to be weaker than normal. In normal function, bone is continually being broken down and replaced by new bone, to keep the skeleton strong. In Paget’s disease, the cells called osteoclasts that break down bone, are overactive. This makes the cells that produce new bone, called osteoblasts, to work faster than normal. The resulting new bone is weak and of poor quality. The cause of the disease is unknown, but there is a strong genetic

Skeletal System Disorders: Paget’s disease The Skeletal system is comprised of joints and bones as well as tendons, ligaments, and cartilage that connect them. Our skeletal system works together with the body to provide movement and protection for humans to live. However, skeletal disorders and diseases can threaten the system causing pain, inability to move, breakage, defects, and other harmful conditions. For instance, Paget’s disease is one that disturbs the normal process of bone growth. About

Osteoporosis is the disease process by which bone remodeling is altered. This alteration is when old bone is insufficiently replaced by new bone (Cosman et al, 2014). New bone growth peaks in the early 20’s and after this age bone mass is lost faster than generated. The lack of new bone replaced can lead to fractures and deformed skeletal architecture. This alteration occurs with menopause, increased age, or long term use of corticosteroids (Cosman et al, 2014) Often the first sign of osteoporosis