Osteoclast

1.The last and final stage of the process of bone rebuilding and remodeling another cell comes into play, the osteoclasts! 2. The bony callus is then remodelled by osteoclasts and osteoblasts. 3.Osteoblasts main function is to build up new bone. These cells secrete the matrix for bone formation. 4.Osteoclasts are the other cell that are present during bone remodeling. Osteoclasts are responsible for eating away at excess bone matrix formed by the

(2003) indicated that, the bone remodeling process regulates the gain and loss of bone mineral density in the human skeleton and directly influenced bone strength and vice versa. In bone remodelling process, resorption of extra-cellular matrices by osteoclasts is followed by osteoblastic invasion of the cavity, and subsequent secretion of extra- cellular matrix that is then mineralized (Ducy et al., 2000). These two processes, which together are called bone remodeling, occur continuously (Riggs et al

exercise are pivotal in the maintenance of bone mass density (BMD), there now several bisphosphonates that can be used to improve BMD. An increase of dietary vitamin D, K and Calcium will also help to strengthen the tight coupling relationship between osteoclasts and osteoblasts which will help to maintain healthy bone structure. c. Hypothetically if Inger had Amenorrhea or Oligomenorrhea, hormone replacement therapy (HRT) (10) could have prevented or delayed the onset of OP. Links have been found to OP

bone fractures each year –in the elderly, these bone fractures can be debilitating or even life threatening (Eastell, 2009). Osteoporosis manifests when an imbalance between bone resorption and bone rebuilding occurs – this is due to changes in osteoclast and osteoblast activity. I chose this topic because osteoporosis affects millions of people, and research will allow me to better understand this common yet complex, and very perilous bone disease. Types: There are two types of osteoporosis, primary

think of osteoclast as the construction workers that come by a road and begin to tire it apart while the osteoblasts will be the crew that will come in afterwards to come and build it. In osteoporosis either too little formation of bone or too much removal of bone occurs as a result of external factors which might be genetic or environmental. One way in which this this can occur is it can be seen in pose menopause of women. Oestrogen is a hormone found in men and women that kill off osteoclasts to prevent

Osteoporosis Definition. Osteoporosis is a progressive bone disease that is characterized by low bone mass along with continuous loss of bone tissue with increased fracture risk. The pathology is multi-factorial and there are several modifiable and non-modifiabale factors that contribute to the development of this disease. According to the World Health Organization, osteoporosis is defined as a systemic skeletal disease illustrated by a decrease in bone mass and bone tissue, causing a decrease

bones during trauma or just natural growth (Van der Kamp, 2012). Bone cells that assist with formation of bone are called osteoclasts, and bone cells that assist with the resorption of bone are called osteoclasts. According to Susan Van der Kamp (2012) when bone is being modified, osteoclasts are driven to the site of modification so they can reabsorb bone. Once the osteoclasts are finished, they usually undergo programmed cell death and

Osteoblasts and osteoclasts are sensitive to pressure. Increase pressure, osteoblasts increases bone. No pressure, osteoclast decreases bone 36. What does exercise do to bone? Exercise increases bone density. 37. What happens if you don’t have enough The body’s calcium needs will come out of the calcium in the blood? bone by an increase in osteoclast activity. The BIO 135 Test 3 (6,7,8,16) Review Sheet 38. What is osteoporosis?

calcitriol, sodium fluoride and bisphosphonate (BP) intake [5]. As a general management strategy, patients should not be taking sedative drugs and for those with reduced mobility an adequate walking aid should be used [2]. LO3. BPs act against osteoclasts and reduce rates of bone resorption

because individuals affected with osteopetrosis do not have normal osteoclasts, which bones need to work correctly. Healthy bones require properly functioning osteoblasts and osteoclasts. Osteoblasts are responsible for making new bones and osteoclasts are bone cells that are responsible for bone resorption, which is the breaking down of bones and providing space for new bone marrow to grow. An individual with osteopetrosis has osteoclasts that do not function properly, therefore their bones are not healthy