Osteoclast

Systemic glucocorticoids are the leading cause of secondary osteoporosis. Osteoporosis is described by the World Health Organization (WHO) as a ‘progressive systemic skeletal disease characterised by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture’. Oral glucocorticoids are the low bone mass and microarchitectural deterioration main iatrogenic cause of fragility fracture. Relationship between glucocorticoid

Progressing to an ageing population, the number of bone disorders and conditions is an increasing problem affecting millions of people today, with osteoporosis being a key example. Bone grafting is one form of a bone regeneration treatment for patients suffering from bone fractures and injuries, congenital abnormalities as well as reconstruction of the bones. Bone regeneration relies on several factors such as defect and graft size, tissue viability, shape and volume and cost. Although, the current

because in children these bones have particularly extensive blood circulation, making them more susceptible to invasion by bacteria. Different patterns of blood circulation in adults make the long bones less well-served by the circulatory system. These bones are therefore unlikely to develop osteomyelitis in adult patients. Instead, the bones of the spine (vertebrae) receive a lot of blood flow. Therefore, osteomyelitis in adults is most likely to affect a vertebra. Drug addicts may have osteomyelitis

Osteoporosis is one of the most common bone disease. It happens when the bones lose a great amount of their protein and mineral content, in particular calcium. This presents an increase in bone fragility and risk of fractures, it is responsible for millions of fractures annually. These fracture are the first sign of the disease, it can affect any bone. Some causes of osteoporosis are malnutrition, poor diet or low physical activities. However the major cause of this diseases is that the loss

The process of bone development and bone growth, as well as maintaining healthy bones, is dependent upon several hormones produced in the body. The hormone Calcitriol, which is produced in the kidneys, plays a key role in the absorption of calcium and phosphate ions within the digestive system. The pituitary gland is responsible for the Growth hormone. It causes the building up of the bones, producing bone growth. The development of the hormone Thyroxine comes from the thyroid gland. Thyroxine prompts

Understanding Osteoporosis What is Osteoporosis? Osteoporosis is a disease that causes bones to become thin, weak and brittle. Throughout your life your bones are replacing old bone tissue with new bone tissue, but as you age that process slows and the body does not produce new bone tissue fast enough. The end results are bones that become more fragile and fractures can occur. This is a “silent” disease without symptoms until the fracture occurs. The most common bones affected are the 1) spine 2)

Senior Care: What are Bone Fractures? According to the American Academy of Orthopedic Surgeons, a fracture is a fancy term for a broken bone. A bone can be completely or partially broken in a number of different directions and ways. The type of fracture is determined by the direction and severity of the break (lengthwise, crosswise, broken into many pieces, pierced the skin, etc.). Bones are strong, but they can only withstand so much pressure. When we are young, there is a certain degree of "flexibility"

Osteoporosis is referred to as the decrease in bone density and mass over time. The interior bones become progressively weaker and can cause a stooped posture. This makes the individual more susceptible to bone fractures. Osteopenia regards a condition where the bone material density is considered lower than normal. This is usually a precursor to the musculoskeletal disorder, known as osteoporosis. The term ‘osteoporosis’ means ‘porous bones’. In this case, bone is a living tissue that is continuously

osteochondroma in mice Abstract Introduction Bones are dynamic tissues that undergo a constant cycle of fracturing, resorbing, and remodeling. Bone mass is reflected by the coupled balance of osteoblasts, which produce bone matrix proteins and osteoclasts, which degrade bone (Miyamoto, 2003). This opposite and complementary activity between these two lineages of cells maintains the homeostasis of bone resorption and formation during bone remodeling. Dysregulation of this process is a major mechanism

phosphorus absorption is by increasing the adsorption by the small intestine. It also increases the calcium and phosphorus released from the bones and does this by binding to osteoclasts. The osteoclasts release a chemical messenger called osteoclast stimulating factor. This causes precursor cells to change into osteoclasts and the osteoclasts break down the bone, thus releasing calcium and phosphorus into the blood. Lastly, it also promotes reabsorption of calcium ions by the kidneys and less calcium is excreted