Statin

Effect of two intensive Statin regimens on progression of Coronary Disease. Citation Nicholls J. Stephen, Ballantyne M. Christie, Barter J. Philip, Chapman M. John, Erbel M. Raimund, Libby Peter, Raichlen S. Joel, Uno Kiyoko, Borgman Marilyn, Wolski Kathy, Nissen E. Steven. Effect of two intensive statin regimens on progression of coronary disease. New England Journal of Medicine. 2011 November 15 (2015 August 24); 365(22). Introduction Clinical trials have shown that statins, inhibitors of 3-hydroxy-3-methylglutaryl

Q# 6. Statins are used to treat patients with coronary heart Disease. How do statins work and why are they considered So beneficial for people with heart disease. Before we consider the role of statins in people with Coronary Heart Disease (CHD), it is important to understand the pathophysiology of CHD and its impact on people’s health. Coronary Heart disease is a condition in which fatty deposits accumulate in the cells lining the wall of a coronary artery, therefore obstructing the blood

treatment options indicates that patients being treated with statin therapy are less likely to develop sepsis from a serious infection, die from sepsis or develop serious complications due to sepsis; however, the mechanism of action is unknown and therefore is the focus of this study [2, 6, 10-12]. Possible mechanisms of action include a direct interaction of the statin with the sepsis-causing organism, an interaction between the statin and the host immune system or a combination of the two [9, 14

(Raleys.com, 2015). Chemical structure and functional groups Simvastatin is one of the statins derivatives that is synthesised from a fermentation product of Aspergillus terreus. The simvastatin is an inactive lactone which is hydrolysed to the β-hydroxyacid form when it is taken orally. β-hydroxyacid form is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A(HMG-CoA) reductase. This enzyme

Atherosclerosis, which leads to the formation of atheromas, is the foundation of cardiovascular disease (CVD). Though much is already known about the benefits of statins, their disease-modifying properties, in regards to inducing the regression of atheroma is still to be elucidated. Previous research has explored atheroma regression in specific diseases, but there is a need for a holistic literature review to come to a definitive conclusion as to whether atheroma reversal can occur. Atherosclerosis

In the U.S., more than 40% of over 65 year olds use starting to control their cholesterol level. According to two new studies, however, the use of statins decreases the effect of flu vaccines. The findings of these studies were published in The Journal of Infectious Diseases. The Centers for Disease Control and Prevention (CDC) recommends that everyone have a shot of the vaccine against flu every season from the age of 6 months. A high-dose of this vaccine is one of several standard-dose vaccines

3: PROPENSITY SCORE MATCHING AND TIME-VARYING CONFOUNDING IN A STUDY OF STATINS AND THE RISK OF VENOUS THROMBOEMBOLISM Aims • To evaluate the association between statin use and the risk of VTE controlling for time-varying confounding. • To examine whether this association differs by body mass index (BMI) • To examine various characteristics of exposure including type of statin, dose of statin, and recency/duration of statin use in relation to VTE risk Study design This study will be a population-based

Background: There is no consensus on the adjunctive statin therapy duration that would provide the maximum advantage in terms of clinical outcomes in bacteremic patients. Objectives: To identify optimal statin adjunctive therapy duration in terms of survival among bacteremic patients. Methods: Using Optum Clinformatics with matched Premier hospital dataset (08/2009-03/2013), we conducted a case-control study to assess inpatient mortality among adult (≥18 years) bacteremic patients who received at

people who are nearing retirement, and a number of of them are taking statins considering they have excessive cholesterol. After I speak about this with them, i will be able to evidently see they're underneath the influence that statins are innocent medicinal drugs. A lot of them additionally believe they'd most likely

The examples of drugs in this class are atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor). Statins is the first line to use for lowing blood cholesterol levels. Statins works by blocking the enzyme called HMG-CoA reductase in the liver which is necessary for making cholesterol. The statins blocks the active site of the HMG-CoA reductase enzyme so that it cannot converse to mevalonate. Therefore, there is more LDL receptor available in the