Pathogenesis Take Home Activity
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University of South Florida *
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Date
Dec 6, 2023
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docx
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Name:___Sanika Kende
______
Lab Section:_901
_
Microbial Pathogenesis Activity: Part II
Take-home writing assignment
You will be working on this assignment individually to utilize the pathogen and review article from Part I
of
this activity, along with one additional source you have found. You can use this word doc as a template to
complete parts A-C below, save, and print hard copy & upload electronic copy to Canvas. (15pt)
Pathogen: _Clostridium difficile
________
A.
Buonomo E., Petri W. A., The microbiota and immune response during Clostridium difficile infection,
Anaerobe, Volume 41, (2016). pages 79-84, ISSN 1075-9964,
https://doi.org/10.1016/j.anaerobe.2016.05.009
Rineh, A., Kelso, M. J., Vatansever, F., Tegos, G. P., & Hamblin, M. R. (2014). Clostridium difficile
infection: molecular pathogenesis and novel therapeutics.
Expert review of anti-infective
therapy
,
12
(1), 131–150. https://doi.org/10.1586/14787210.2014.866515
B.
The additional article I have found and listed above is classified as a review article as it is reviewing
the structure and mechanism of action of toxins A and B, rather than providing new research and
disseminating the results.
C.
C. difficile
is a gram-positive, anaerobe gastrointestinal bacterium that can cause many diseases
such as diarrhea and colitis (Rineh et, al, 2014). The
C. difficile
pathogenicity locus, which is a 19.6-
kb chromosomal region, contains the genes for toxins A and B, also known as TcdA and TcdB; these
toxins make use of their cytotoxic activity by modifying cytoskeletal components (Buonomo et. al,
2016). This mechanism is carried out through the fact that the toxins are glucosyltransferases that
“irreversibly inactivate small Rho GTPases,” which disrupts cytoskeletons and tight junctions and
eventually leads to cell death in the host (Buonomo et. al, 2016). This mechanism allows for the
pathogenicity of the toxins to spread.
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