F23B1E3%5BPractice%5DFinal

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University of Pittsburgh *

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0110

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Biology

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Apr 3, 2024

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Bio1. Quiz 3 Last Name [Print]: First name [Print]: Student ID # [Print]: Indicate your recitation section [All Tuesday]: R1 @ 9 am R2@ 10 am R3@ 12 pm R4@ 1 pm Please note by submitting the Exam you are agreeing with the following academic statement : "I acknowledge that I am aware of the University of Pittsburgh’s student code of conduct, and the Dietrich School of Arts and Sciences policy concerning academic honesty, integrity, plagiarism, and cheating. I further attest that the work I am submitting with this exam is solely my own and was developed during the exam. I have accessed only my permitted materials during the exam. I have not recorded an image of this exam, nor have I had any contact with a fellow student during the exam. I further attest that I hold myself to the high academic standards expected of me." Violation of the academic integrity statement will result in a zero score being applied, which cannot be dropped from your final grade. Signature: Score Card You may detach the scorecard, but ONLY the scorecard as you work. All pages of this exam must be returned before you leave the classroom. Section 1: Fill in the blank section Please transfer your final answers to the corresponding box below. Your answer should be a scientific description or term (2 words max). Only answers in the scoring card will be accepted. If a response is not clearly legible, or you enter multiple answers, no points will be awarded for that question. [1 point each] Blank 1 Blank 2 Blank 3 Blank 4 Blank 5 Blank 6 Blank 7 Blank 8 Blank 9 Blank 10

Bio1. Quiz 3 Section 2: Open response. Enter response(s) as per question prompt. Only answers in the scoring card will be accepted. If a response is not clearly legible, or you enter multiple answers (unless otherwise directed), no points will be awarded for that question. [2 points each] Q.11 Letter sequence in correct order Start=> =>End Q.12 Responses Occurring: Not occurring: Q.13 Letter Q.14 Agonist: Antagonist: Q.15 Kinesin to: Dynein to: Q.16 Process Q.17 Cross-section Q.18 Arrow Q.19 A. B. C. Q.20 Number MI: Section 3: Multiple-Choice section. Enter the corresponding letter for your [one] answer choice. If you enter multiple responses per question, or if your letter choice isn’t clearly legible no points will be awarded for the question [2 points each] Q.21 Q.22 Q.23 Q.24 Q.25 Q.26 Q.27 Q.28 Q.29 Q.30 Q.31 Bonus

Bio1. Quiz 3 Last Name [Print]: First name [Print]: Student ID # [Print]: Indicate your recitation section [All Tuesday]: R1 @ 9 am R2@ 10 am R3@ 12 pm R4@ 1 pm Reference Tables DO NOT DETACH THE REFERENCE TABLES OR ANY OTHER PAGES FROM THE EXAM Section 1: Fill in the blank Select the correct scientific word(s), term, or description to complete the sentence (2 words max). Please transfer your final answers as [directed in the question prompt] to section 1 of the scorecard. Only answers on the scorecard will be accepted. Please write legibly; if your answer isn’t clearly legible no points will be awarded for the question. The fill in the blank questions are worth 1 point each. Q.1 The <Blank 1> system consists of the nucleus, endoplasmic reticulum, golgi, lysosome and cell membrane (term describing this collection of organelles). Q.2 A <Blank 2> coated vesicle moves vesicles from the Golgi to the cell membrane (type of vesicle coat). Q.3 <Blank 3> describes the interaction between multiple pathways involving secondary messengers, to have a coordinated cellular response (term describing this specific interaction). Q.4 <Blank 4> filaments anchor cell structures in place within the cell (specific cytoskeletal component). Q.5 Signal transduction ends with the cellular <Blank 5> component of a signaling pathway (one of the three sections of cell signaling). Q.6 An <Blank 6> receptor is a membrane receptor which allows for direct facilitated diffusion of ions upon ligand binding (type of receptor). Q.7 The intracellular non-protein components of a signaling pathway are collectively called <Blank 7> (Term for components seen more frequently with membrane receptors).

Bio1. Quiz 3 Q.8 In a pathway where molecules are broken down and ATP is produced this is a <Blank 8> process (term encompassing all break-down reactions). Q.9 The <Blank 9> model for enzyme-substrate interaction describes a change in enzyme shape upon substrate binding in the active site (term describing the enzyme shape change). Q.10 Enzymes speed up biochemical reactions by lowering the <Blank 10 > of the reaction (term describing the energy change). Transfer your final answer to Section 1 of the ScoreCard on Page 1 => Section 2: Open Response. Please transfer your final answer to the scorecard. Only answers on the scorecard will be accepted. You may detach this scorecard as you work but must return both the scorecard and exam before leaving the classroom. For this section, please enter your response as directed in the question prompt. If you enter multiple responses (other than directed) per question, or if your response isn’t clearly legible, no points will be awarded for the question. Q.11 Build your pathway. Put the components in the box in the correct order in which they function in a signal transduction pathway. In this pathway the receptor is a G-protein coupled receptor, and the second messenger activates the kinase cascade. Phosphorylation of the transcription factor is the cellular response. Note: All components will be used one time in this signal transduction. A. Transcription factor phosphorylation B. Primary Message binding C. cAMP levels increase D. Kinase cascade activation E. Receptor activation F. Adenylate Cyclase (AC) activation G. G protein activation Start => => => => => => => => End Transfer your final answer to Section 2 of the ScoreCard on Page 2 =>

Bio1. Quiz 3 Q.12 Crosstalk allows cells to integrate multiple signals for a coordinated cellular response. Below is a graphical representation of four signaling pathways. The circles represent a kinase cascade (K1-4) in the signal transduction of the pathway, and the response is noted in the box at the bottom of each pathway. The inhibitory (attenuated) and stimulatory crosstalk via second messengers is indicated. Which cellular responses would occur if ligand was bound at receptor A, B and D (C is unstimulated, with no ligand bound). Responses occurring: Responses not occurring: Transfer your final answer to Section 2 of the ScoreCard on Page 2 => Q.13 The hydrolysis of ATP is as follows: ATP → ADP +Pi ΔG o = -7.3 kcal/mol. Which reaction would the hydrolysis of one ATP molecule most likely be coupled to? Reaction: Transfer your final answer to Section 2 of the ScoreCard on

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