Week 4 Case Study Natural Killer Cell Deficiency

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Chamberlain College of Nursing *

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Biology

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Jan 9, 2024

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Week 4 Case Study Natural Killer Cell Deficiency 1. Natural killer cells defend the body against infections and sick host cells. Their mission is to target and destroy bacteria, infected viral cells, and even cancer cells. Because of their distinct appearance, the presence of many lymphoid markers, and the fact that lymphoid cells originate in the bone marrow from a comparable progenitor cell, NK cells have been classified as lymphocytes (Vivier et, al, 2011) 2. Natural Killer (NK) cells are highly effective in combating cells that have been infected by viruses as well as cells that have the potential to form tumors. 3. As soon as the NK cell spots a threat, it starts to release proteins called perforins. It's amazing how these proteins can arrange themselves in a circle and make a hole in the plasma membrane. The opposing cell will eventually die because this hole will make it easier for salt and water to get in. Sometimes, the function of cells may be harmed, which could lead to cell death. But the NK cell will also release granzymes, which are a unique group of enzymes that break down proteins. This means that macrophages can eat germs, dead cells, and other foreign substances. Furthermore, they have the power to alert the immune system to the presence of a possible threat.
4. It is vital to remember that NK cells play an important part in our body's natural immune response to infections as well as cancer. As a result, it is understandable that the immunologist informed her that she may be predisposed to developing cancers caused by viruses. She has a decrease in the activity of her natural killer cells, which puts her at risk. Natural killer cells serve an important part in protecting our health. 5. Shanice should consult with her healthcare provider regarding her available options. She can begin implementing prophylactic measures by initiating medication regimens that can assist in managing conditions impacting the immune system. She can optimize her immune system and response by eating a healthy diet. Saladin, K. S. (2020). Anatomy & Physiology: The Unity of Form and Function (9th ed.). McGraw-Hill Higher Education (US). https://online.vitalsource.com/books/9781260791563 Vivier, E., Raulet, D. H., Moretta, A., Caligiuri, M. A., Zitvogel, L., Lanier, L. L., Yokoyama, W. M., & Ugolini, S. (2011). Innate or adaptive immunity? The example of natural killer cells. Science (New York, N.Y.) , 331 (6013), 44–49. https://doi.org/10.1126/science.1198687
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