Experiment 5

Reactions of Carboxylic Acids - Fisher esterification: Acid-catalyzed ester formation from carboxylic acid and alcohol OH H₂SO4 OH - Carboxylic acid: conversion to acyl halides: SOCI₂ RCO₂H + SOCI₂ (w/ pyridine) → RCOCI SOCI₂ CH3OH CH3COH Reactions of Amide NH₂ 1. LiAlH4 2. H₂O

Propose a method to separate a mixture containing phenol, benzoic acid, naphthalene, and p-nitroaniline. Phenol is soluble in sodium hydroxide solution but insoluble in neutral water or sodium bicarbonate solution. Benzoic acid is soluble in either sodium hydroxide or sodium bicarbonate solutions. Write out the structures of the molecules in your scheme.

Restate the paragraph. The main objective of the laboratory activity was to make aspirin also known as acetylsalicylic acid in its scientific name. It was successfully done as aspirin was synthesized using the combination of salicylic acid and acetic anhydride. In this reaction, salicylic acid's hydroxyl group on the benzene ring interacted with acetic anhydride to generate an ester functional group. This is an esterification reaction that produces acetylsalicylic acid. Sulfuric acid was utilized as a catalyst to start the esterification reaction. Some unreacted acetic anhydride and salicylic acid, as well as sulfuric acid, aspirin, and acetic acid, remained in the solution after the reaction was completed. The process of crystallization was used to obtain pure crystals of a substance from an impure mixture. Upon completion of the lab, analysis, and calculations, , it is evident that the synthesis of aspirin is possible using these methods but that the yield will be relatively low

Researchers at Rutgers University have developed biocompatible polymers that degrade into nonsteroidal antiinammatory drugs. For example, the reaction of two equivalents of benzyl salicylate and one equivalent of sebacoyl chloride forms a poly(anhydride ester) called PolyAspirin, which hydrolyzes to salicylic acid (an anti-inammatory agent) and sebacic acid, which is excreted. This technology can perhaps be used for localized drug delivery at specic sites of injury. What is the structure of PolyAspirin?

Prepare cyclomethine dyes (comp 4) using condensation reaction H₂C₂ 21389 4 [34708-09-3] 3-phenylpyrazoline N-ethylnaphtholactam. CI™

Several sulfonylureas, a class of compounds containing RSO2NHCONHR, are useful drugs as orally active replacements for injected insulin in patients with adult-onset diabetes. These drugs decrease blood glucose concentrations by stimulating b cells of the pancreas to release insulin and by increasing the sensitivity of insulin receptors in peripheral tissues to insulin stimulation. Tolbutamide is synthesized by the reaction of the sodium salt of p-toluenesulfonamide and ethyl N-butylcarbamate . Propose a mechanism for this step.

6 4.00 8 7 6 2.95 7.820 7.791 -7.756 7.727 5 4 3 2 1 ppm -3.911 — 1H of Methyl-4-iodobenzoate in CDC13

determine the plausible identity of the compound from the given possible compounds.

A student attempted to prepare 1-chlorobutane by mixing 1-butanol with NaCl in acetone. Was the student succesful? Explain.

PLEASE HELP ASAP determine the plausible identity of the compound from the given possible compounds.

Select the best pair of answer below justifying the reason for your choice.

Chemistry why dose the reaction of an amine with formic anhydride occur at room temperature,while the reaction of an amine with acetic anhydride needs a temperature of about 50-60 C ?