Aspirin Synthesis

In a 0.73 mM aqueous solution of trimethylacetic acid (C₂H₂CO₂H), what is the percentage of trimethylacetic acid that is dissociated? You can find some data that is useful for solving this problem in the ALEKS Data resource. Round your answer to 2 significant digits. 1% 00 x10 X $

1. For alcohol protecting groups, there are many options, including converting the alcohol to an ester (we will see this in Chapter 20). In the context of organometallic chemistry, why would an ester be a poor choice? Use the following reaction as an example and point out what could/ would happen. Mg OH then 2. I did not quite get to it, but organometallic reagents can react with other functional groups beyond carbonyls. One significant example is epoxides. Given that they are strong nucleophiles, what do you think would be the product of the following reaction. i 3. And then synthesis. Outline how you could covert the given ester to the given tertiary alcohol. Note that you may have to look at chapter 17 for a review of some older reactions if you do not remember them. from

Please fill in the charts for the ester lab (chemistry)

On synthesis of esters via nucleophilic acyl substitution: How is excess alcohol eliminated from the crude product? Write the chemical equation involved in the reaction between the excess acid and NaHCO3. Given this, briefly explain why NaHCO3 is preferred over NaOH for the neutralization of excess acid.

In this lab you are performing your first organic synthesis and safety information on all the materials you are using must be obtained. Companies are required to provide material safety data sheets (MSDS) for chemical compounds they sell. Please examine the MSDS for acetic anhydride, available here. You will find GHS pictograms within the sheet that summarize the main hazards of this compound. The pictograms are essentially the same as the symbols on WHMIS labels, available here for reference. Based on the pictograms, whatare the main hazards for acetic anhydride? Select as many answers as appropriate Select one or more: Carcinogen Gas under pressure Acute oral or inhalation toxicity Corrosive Flammable material Oxidizing material Self-reactive substance

On synthesis of esters via nucleophilic acyl substitution: Write the chemical equation involved in the reaction between the excess acid and NaHCO3. Given this, briefly explain why NaHCO3 is preferred over NaOH for the neutralization of excess acid. Also, explain how excess alcohol was eliminated from the crude product.

Find the structural formulas for salicylic acid, acetic anhydride, and aspirin. Use these structural formulas to construct a reaction equation describing the synthesis of aspirin.  (CH3CO)2O + HOC6H4COOH → CH3CO2C6H4CO2H + CH3COOH acetic anhydride   salicylic acid   acetylsalicylic acid   acetic acid Part I  Synthesis of Aspirin Mass of salicylic acid used (g)  2.029g Volume of acetic anhydride used (mL)  5ml Mass of acetic anhydride used (vol. × 1.08 g/mL)  5.4g Mass of aspirin synthesized (g)  3.256g Part II  Melting Temperature Data Melting temperature (°C)  133°C Part III  Salicylic Acid Standard Stock Solution Initial mass of salicylic acid (g)  0.210g Moles of salicylic acid (mol)  0.0147 mol Initial molarity of salicylic acid (M)  0.724 M Part III  Beer’s Law Data for Salicylic Acid Standard Solutions Trial Concentration (M) Absorbance Water (mL) 1  10  0.301 0…

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Figure 3 shows a substitution reaction between triphenylmethyl chloride and an excess of the base methanamine. What is the minimum mass of this amine required to produce 5.000 grams of the organic product N-methyltriphenylmethanamine? Molar masses are given in Figure 3. [Round the answer to three decimal places. Do not type in the unit. Use a decimal point.] * Do you need to add imidazole to the reaction mixture used in this question to absorb the hydrogen chloride gas produced during the reaction?

Write TRUE if the underlined word/phrase makes the statement correct. Otherwise, write the correct WORD/PHRASE that will make the statement true. a. 2-phenylacetaldehyde is soluble with concentrated sulfuric acid due to acid-base neutralization. b. 2-phenylacetic acid has a solubility classification of A2, which means it is soluble in 5.O%NaOH and insoluble in 5.O% NaHCO3. c. Scratching the inner sides of the beaker to begin recrystallization is advised for unsaturated solutions. d. Washing with hot solvent eliminates adhered mother liquor and avoids crystal dissolution. e. To extract a nonpolar organic compound using solvent extraction, the extracting solvent must be nonpolar, and the washing solvent must be also nonpolar. f. Addition of 6.0 M NaCl extracts saponins by converting them to their salt form. g. The stationary phase in the paper chromatography experiment is the filter paper. h. When the spots have low concentration, they will not be observed as visible spots in the…

4. You are given a mixture of sodium benzoate and cyclohexylammonium chloride (structures below) that are dissolved in water at pH 7.0. You enter the lab and quickly find a separatory funnel, an organic solvent, sodium hydroxide, concentrated hydrochloric acid, and water. Devise a way to separate these two molecules using a simple organic extraction method. Clearly indicate which molecule is in the organic layer and which molecule is in the aqueous layer. Justify your method by describing what is happening at the molecular level. NH3* Cl- Na+ pka = 4.2 pka = 11.2 %3D

Why does the dehydration of an alcohol more often use concentrated sulfuric acid,  H2SO4H2SO4, as the acid catalyst rather than dilute hydrochloric acid, HCl?   Select one or more:   Hydrochloric acid is too small to effectively react with the alcohol in the reaction.   The additional water solvent from a dilute solution could reverse the dehydration reaction.   Only acids with more than one proton can complete the dehydration reaction.   The presence of the chloride ion could result in a competing substitution reaction.

Which solvent(s) would be suitable for substitution reactions using NaCN? Acetonitrile Benzene Diethyl ether Methanol (MeOH) Dimethylformamide (DMF) Acetone. Isopropanol

In a small laboratory, the following organic synthesis was under performance. However, the sample had caught fire and ignited. What type of extinguishing method should be taken? If a fire extinguisher is used what type of it should be used? Explain the reasoning behind your choices

Organic Functional Groups Predicting the reactants or products of ester hydrolysis Predict the products of this organic reaction: 0 CH—C—0—CH, H C-CH3 + H₂O Specifically, in the drawing area below draw the condensed structure of the product, or prod in any arrangement you like, so long as they aren't touching.) If there aren't any products because this reaction won't happen, check the No reaction box un

Consider a ternary (three-component) system of amphiphile, hydrocarbon, and water. What structure do you expect to form if small amounts of the first two components are mixed with a large amount of water?

Predict the most likely product of this biochemical reaction: CH₂= OH O + Pi X + H₂O That is, in the drawing area below, draw the chemical structure of the product molecule X. Note for advanced students: you can assume any necessary small-molecule reactants, like water, are available. Predicting reactants or products of phosphorylation Click and drag to start drawing a structure. X Ś (

You are employed as a coop student at the Drug and Alcohol Testing Association of Canada (DATAC) developing analytical tests for sports doping agents. You are asked to prepare a procedure for the extraction of methylphenidate, the active compound in Ritalin, from urine samples (consider them as simple aqueous layers, you do not need to consider other components!). The goal of the procedure is to extract the methylphenidate into an organic layer which will then be evaporated, and the residue will be tested for the drug.You find that methylphenidate is highly soluble in 2-methyltetrahydrofuran, a bio-renewable solvent. Draw the structure of 2-methyltetrahydrofuran and give two reasons why it is a good solvent choice for liquid-liquid extraction.

Restate the paragraph. The main objective of the laboratory activity was to make aspirin also known as acetylsalicylic acid in its scientific name. It was successfully done as aspirin was synthesized using the combination of salicylic acid and acetic anhydride. In this reaction, salicylic acid's hydroxyl group on the benzene ring interacted with acetic anhydride to generate an ester functional group. This is an esterification reaction that produces acetylsalicylic acid. Sulfuric acid was utilized as a catalyst to start the esterification reaction. Some unreacted acetic anhydride and salicylic acid, as well as sulfuric acid, aspirin, and acetic acid, remained in the solution after the reaction was completed. The process of crystallization was used to obtain pure crystals of a substance from an impure mixture. Upon completion of the lab, analysis, and calculations, , it is evident that the synthesis of aspirin is possible using these methods but that the yield will be relatively low

4. Using structures for all species, write the complete esterification reaction begun below: HSO, methanol (CH3OH) + salicylic acid

You want to determine the molar mass of the polymer shown below by end group analysis using acid-base titration. 15 grams of this polymer dissolved in water consumed 6 mL of 0.1 M NaOH. What is the number average degree of polymerization (disregarding end groups)? но OH 1136 462 398 236 568

SYNTHESIS OF ESTERS VIA NUCLEOPHILIC ACYL SUBSTITUTION Write the chemical equation involved in the reaction between the excess acid and NaHCO3. Explain why NaHCO3 is preferred over NaOH for the neutralization of excess acid.  How was excess alcohol eliminated from the crude product.

only the questions pls disregard the experiment results thank you

What functional group is present in the reactants (isobutanol, sulfuric acid, Dichloromethane, sodium carbonate) but not in the ester? What wave number range in the IR spectrum does the peak appear and what does it look like?

Estrogens are female sex hormones, the most potent of which is B-estradiol. OH AYA Но B-Estradiol In recent years, chemists have focused on designing and synthesizing molecules that bind to estrogen receptors. One target of this research has been nonsteroidal estrogen antagonists, compounds that interact with estrogen receptors and block the effects of both endogenous and exogenous estrogens. A feature common to one type of nonste- roidal estrogen antagonist is the presence of a 1,2-diphenylethylene with one of the benzene rings bearing a dialkylaminoethoxyl substituent. The first nonsteroidal estrogen antagonist of this type to achieve clinical importance was tamoxifen, now an important drug in the treatment of breast cancer. Tamoxifen has the Z configuration shown here. NMeg A B NMeg ? ОН Tamoxifen Propose reagents for the conversion of A to tamoxifen. Note: The final step in this synthesis gives a mixture of E and Z isomers.

Hi! I am working on some Organic Chemistry homework and one of the questions asked what would happen if Butanol was used as a solvent instead of water when mixed with methanol,ethanol, and hexan-1-ol

Why are alcoholic solutions (alcoholic NH2OHꞏHCl, alcoholic KOH, alcoholic HCl) used in the hydroxamic acid test for esters? Please don't answer if you've answered this already.

Provide both a model and structural formula for each question.

4. A student prepared a compound. The melting point of the crude product was 42 to 48°C. After purifying the solid for the first time, the melting point was 47 to 51°C. After another purification, the melting point was 50 to 53°C. At this stage, can the student confidently say the product has been completely purified? Justify your answer. ied