fishbone translational research
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School
Middle Tennessee State University *
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Course
2304
Subject
Medicine
Date
Feb 20, 2024
Type
docx
Pages
4
Uploaded by UltraPorpoise3975
This assignment will require that you explore your resources. Key words are important in locating the information you need to complete this assignment. By now, the expectation is that you are more comfortable and competent to seek the information required for your understanding and application. With that in mind, Let's tap into your creative side. Please demonstrate your understanding of translational science by either creating a concept map or making a small PowerPoint presentation using six slides or less not including the title or reference page to incorporate the following components of this science:
1) Illustrate the relationships of the T phases of translational health research with descriptions/examples of each phase
Translational research is a dynamic continuum from basic research through application of research
findings in practice, communities, and public health settings to improve health and health outcomes;
progresses across five phases:
1.
“Preclinical and animal studies (T0/basic science research)”: It is depicted as recognition of
opportunities and methodologies to health problems
(
www.iths.org). For example, are there
specific gene mutations related to breast cancer?
2.
“Proof of concept/ Phase 1 clinical trials (T1/testing efficacy and safety with small group of
humans)”: T1 phase move basic discovery into a candidate health application
(www.iths.org/investigators). For instance, Is there any connection between BRCA mutations and
breast cancer?
(medschool.ucsd.edu)
3.
“Phase 2 and 3 clinical trials (T2/ translation to patient): “Controlled studies leading to effective
care
” (
tri.uams.edu). “T2 research translates successful application in humans into wider use in
widespread clinical practice, into patient population, and other approaches to further define the
appropriateness of treatment and tests in clinical area” (www.tuftsctsi.org). For example, “Phase
3 clinical trial Comparative effectiveness trial phase 4 clinical trial”
(
Zarbin, M. 2020, July 14).”
Another example, what is the positive predictive value of BRCA mutations in at-risk women?”
(medschool.ucsd.edu)
4.
“Phase 4 clinical trials and clinical outcomes research (T3/Translation to practice)”
(tri.uams.edu). It consists of delivery of suggested and prompt care to the right patient (tri.uams.edu/). T3
research provides knowledge about how interventions work in real world settings
(
www.tuftsctsi.org). As an example, “What proportion of women who meet the family history
criteria are tested for BRCA and what are the barriers to testing?”
/(medschool.ucsd.edu)
5.
Phase 4 population-level outcomes research (T4/translation to community): T4 seeks to assess the
health outcomes of actual world people (www.iths.org). For example, “T4 consists of policy
assessment and evaluation, cost-benefit analysis, and observation studies and research questions
which concentrate on the intervention “as used”, rather than according to a research protocol”
(
www.tuftsctsi.org
). Another example, “Does BRCA testing in asymptomatic women reduce
breast cancer incidence or improve outcomes?”
(medschool.ucsd.edu).
2) Provide an example of a health issue that has been improved using these phases of translational Research
Translational science has played a great role in improving the health and wellbeing of the people.
Translational research uses the most current findings in basic science, tests compounds, measures its
effectiveness in clinical trials, and finally implements results in large scale production (Jayakumar J.
et.al 2019). As an example, many people lost their lives with the outbreak of Covid in 2019.
Translational science aided with the development and delivery of SARS-CoV-2 diagnostic services as
illustrated in the journal published in journal PLOS (Edgeworth JD et.al 2020). Also due to the
advancement in Translational science, Covid vaccines could be manufactured in a large scale within a
short period of time saving lives of many people. 3) Relay why the use of translational research is important to your future practice as an Advanced Practice Nurse (FNP or MHNP). This assignment is worth 7 points.
As an advanced practice nurse the use of translational research can have several advantages. First of all, it
helps the Nurse practitioner to offer reliable treatment to the patient. Translational research brings various
new treatment and medication in the market only after testing in the people. Hence it is safe to implement
in the people. Secondly, translational science is making possible to diagnose the disease early. As an example, Indiana
Alzheimer Disease center is working on new methods to diagnose, treat and prevent Alzheimer disease.
Longitudinal Early-Onset Alzheimer’s Disease Study is in progress at Indiana University School of
Medicine to develop clinical and biomarker measures for clinical and research use for this disease.
Researcher also use advanced brain imaging technique to detect Alzheimer disease before the appearance
of symptoms. Hence, brain imaging and biomarkers provide foundation for the treatment of the disease.
Thirdly translational research provides the nurse practitioner with framework to conduct various research activities. Nurse practitioners need research because it helps them improve their field and offer better patient care.
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