Powder flow and compounding of capsules_Deferred

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Royal Melbourne Institute of Technology *

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BUSM 3194

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Medicine

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Dec 6, 2023

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docx

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Uploaded by omarrahim97

Practical – 2 (Deferred) Powder flow and capsule compounding PHAR1016 – Essential Medicine Formulations Semester 2, 2022 Declaration: 1. This work is my/our original work and no part of it has been copied from any other student’s work or from any other source except where due acknowledgement is made. 2. No part of this work has been written for me/us by any other person except where such collaboration has been authorised by the lecturer/teacher concerned. 3. I give permission for this work to be reproduced, communicated, compared and archived for the purpose of detecting plagiarism. 4. I give permission for a copy of my marked work to be retained by the school for review and comparison, including review by external examiners. 5. I understand that plagiarism is the presentation of the work, idea or creation of another person as though it is my/our own. It is a form of cheating and is a very serious academic offence that may lead to exclusion from the University. Plagiarised material can be drawn from, and presented in, written, graphic and visual form, including electronic data and oral presentations. Plagiarism occurs when the origin of the material used is not appropriately cited. 6. I understand that plagiarism includes the act of assisting or allowing another person to plagiarise or to copy my work. Student Name ID: S …………………… Signature Date: …… / …… / 2022 Session Tuesday (8:30 – 10:30 am) Tuesday (10:30 – 12:30 pm) Tuesday (1:30 – 3:30 pm) Tuesday (3:30 – 5:30 pm) © Pharmacy Discipline - SHBS – STEM College – RMIT University RMIT Classification: Trusted

Safety in the laboratory It is important that you review the Laboratory induction videos which are uploaded in Canvas before you come to the laboratory. In these videos, you will learn about the principles of safe working in the laboratory, the dress code, the precautions and how you should behave in different situations. Each practical session will begin with a safety briefing which will discuss the specific safety issues related to the practical class. Attending the safety briefing is a condition to complete the class. What to bring with you? - A copy of this report - Lab coat - Safety glasses - Wear appropriate footwear (fully enclosed). - RMIT highly recommends the use of masks while indoors to reduce the transmission of COVID-19. Learning outcomes By the end of this practical, students should be able to: 1. Measure the angle of repose for powders. 2. Measure the bulk density of powders. 3. Classify the powder flowability through the angle of repose method and Carr’s index. 4. Calculate the amount of diluent and capsules needed for a prescription of capsule formulation 5. Demonstrate understanding of extemporaneous compounding of capsules 6. Write the working formula for extemporaneously compounded product. 7. Justify the selection of appropriate capsule size CHEM1290/Pharmacy//SHBS/STEM/RMIT Page 2 of 11 RMIT Classification: Trusted

Introduction Capsules are considered the most versatile of all dosage forms. Capsules are relatively easy to manufacture and commonly used to compound amended formulations by compounding pharmacist. Pre-lab activities : - Watch lab induction videos in Canvas - Review lecture notes on powder module (Part 1) - Review lecture notes on capsules module (Part 1) - Read the relevant pages in chapter 12 of Aulton’s Pharmaceutics (5 th Edition) - Review APF information on extemporaneous compounding (formulary – capsules) Experiment Design The practical is divided into three parts. You will be assigned into a group after the safety briefing. Every group will be required to complete the three experiments to collect the data. In the first experiment, each group will measure the angle of repose of different materials using the fixed height cone method. In the second experiment, students will measure the bulk density of different materials. In the third part, students will complete the working formula for a prescription of calcium carbonate capsules and compound the prescription. The report includes additional question linking the data collected to the theory covered. Report must be completed individually and submitted online by the due date (See the assignment tab in Canvas). CHEM1290/Pharmacy//SHBS/STEM/RMIT Page 3 of 11 RMIT Classification: Trusted

Part 1 — Angle of repose Equipment: - Holder - Funnel - Funnel holder - A4 coloured paper - Balance brush - Spatula or scoop - Ruler - Pen/pencil Materials: - Calcium carbonate - Lactose monohydrate Procedure: 1. Ensure the funnel is attached to the holder at a fixed height (3 cm) and is above the centre of the coloured A4 paper. 2. Using the spatula/scoop, gradually and gently add first compound in the funnel. The compound will start to form a cone shape on the paper. 3. Continue adding the material until the tip of the powder cone reaches the bottom tip of the funnel. 4. Using a pen/pencil circle the cone base on the paper. Ensure that your plotted circle covers most of the powder cone base (roughly not less than 90% of compound at the base). 5. Record the diameter and the height of the cone formed. 6. Transfer the powder from the paper to an empty open-mouth jar. 7. Repeat steps 1-6 three times. 8. Repeat steps 1-7 for the second compound. Question 1.1: The diameter and the height of the cone formed for each compound was recorded in Table 1 (below). Calculate the average diameter (± SD) for each compound. [4 marks] Table 1: Diameter of the powder cone resulted from the angle of repose for calcium carbonate and lactose monohydrate Material Diameter of the cone base (cm) Replicate #1 Replicate #2 Replicate #3 Average ± SD Calcium carbonate 4.8 4.9 5.1 Lactose monohydrate 5.9 6.2 5.8 Question 1.2: CHEM1290/Pharmacy//SHBS/STEM/RMIT Page 4 of 11 RMIT Classification: Trusted

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