Semester_One_Final_Examinations_2021_BIOM2052

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2052

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Apr 3, 2024

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Semester One Final Examinations, 2021 BIOM2052 Integrated Physiology and Pharmacology for Dentistry Page 1 of 22 This exam paper must not be removed from the venue Venue ____________________ Seat Number __________ Student Number |__|__|__|__|__|__|__|__| Family Name ____________________ First Name ____________________ School of Biomedical Sciences EXAMINATION Semester One Final Examinations, 2021 BIOM2052 Integrated Physiology and Pharmacology for Dentistry This paper is for St Lucia Campus students. Examination Duration: 90 minutes Reading Time: 10 minutes Exam Conditions: This is a Closed Book examination - no written materials permitted Casio FX82 series or a calculator on the UQ approved list permitted During reading time - write only on the rough paper provided This examination paper will be released to the Library Materials Permitted In The Exam Venue: (No electronic aids are permitted e.g. laptops, phones) None Materials To Be Supplied To Students: 1 x Multiple Choice Answer Sheet Additional exam materials (e.g. answer booklets, rough paper) will be provided upon request. Instructions To Students: Students are required to write their Name and Student Number on the front cover and each new section of the examination paper, as well as the MCQ marking sheet. For Examiner Use Only Question Mark Total _________
Semester One Final Examinations, 2021 BIOM2052 Integrated Physiology and Pharmacology for Dentistry Page 2 of 22 Instructions for Completing your MCQ Answer Sheet 1. The computer answer sheet must be handled with care. [Do not curl, crease, fold, staple or pin.] 2. Use only HB or B pencils . Press firmly. [Do not use any H-grade pencil, ball-point pens, or ink pens.] 3. • Print your surname and initials (without full stops) in the line of large boxes under the headings "SURNAME" and "INITS". • Shade in completely the corresponding box beneath each letter. [If your surname consists of two or more words, is hyphenated (-), or has an apostrophe ('), shade the blank box above the A at the top of the surname area.] • Repeat this procedure for "STUDENT NUMBER". 4. Complete, in the space provided: "COURSE CODE" and "DATE". 5. Complete the answer boxes by shading the appropriate box completely . Do not extend the shading outside the box area. 6. Take care when making corrections. Erased marks must be completely erased . 7. Ask for a new answer sheet if you have made too many erasures. Check List ➢ Have you completed the "Surname" and indicated at least one initial? ➢ Is your "Student Number" indicated correctly? ➢ Have you indicated the "Course code" and the "Date" in the space provided? ➢ Have you shaded ONE response only to every multiple-choice question on your exam paper? ➢ Have you completely erased all unwanted marks? Good Luck! S A M P L E O N L Y
Semester One Final Examinations, 2021 BIOM2052 Integrated Physiology and Pharmacology for Dentistry Page 3 of 22 …….…..…..…….…...……. …………….…………………...………… ………….. Student Number Surname Initials SECTION A – MULTIPLE CHOICE Recommended time = 42 minutes Number of questions = 28 _______________________________________________ ➢ Only ONE correct response is possible for each question ➢ For each question indicate your answer (A – E) in the corresponding numbered space on the computer answer sheet ➢ Each question carries equal marks ________________________________________________________________________________ 1 G protein-coupled receptors (GPCRs) [1.5 marks] A are directly involved in ion passage through the membrane B contain a single transmembrane spanning domain C induce very rapid (millisecond) cellular effects D result in the production of a second messenger which mediates the intracellular response E are mainly located in the cell cytosol [55863] 2 Considering the effects of repeated oral dosing with a drug at different dose levels and frequency, which of the following statements is INCORRECT? [1.5 marks] A More frequent administration of smaller doses will result in less variation of the drug plasma levels over each dosing interval B The smallest dosing interval of a drug that is rapidly absorbed will result in a plasma concentration profile similar to an intravenous infusion C If a patient showed drug toxicity, it would be better to halve the dose until the plasma concentration is in the safe range than to stop administration completely for that period D Less frequent administration of drugs (e.g. once daily compared with four times daily) is likely to result in greater patient compliance with the dosing regimen E Less frequent administration of large doses can result in the plasma levels fluctuating outside the safe therapeutic range during each dosing interval [55891]
Semester One Final Examinations, 2021 BIOM2052 Integrated Physiology and Pharmacology for Dentistry Page 4 of 22 Background Information for Questions 3 & 4 The graph below shows the response of airway smooth muscle tissue to increasing concentrations of isoprenaline, in the presence of 0 (blue line), 10 -8 M, 10 -7 M and 10 -6 M of a β -adrenoceptor antagonist drug. Answer Questions 3 & 4 based on this information. 3 The EC 50 of isoprenaline in the airway smooth muscle tissue is closest to [1.5 marks] A 3.2 x 10 -8 M B a value that cannot be determined from the information provided C 1 x 10 -9 M D 3.2 x 10 -11 M E 50% [55842] 4 What type of antagonism of the responses of the tissue to isoprenaline is shown with the increasing doses of the β -adrenoceptor antagonist (red curves)? [1.5 marks] A chemical B reversible competitive C non-competitive D pharmacokinetic E irreversible competitive [55852] 5 Which of the following hormones is NOT a polypeptide hormone? [1.5 marks] A insulin B prolactin C oxytocin D thyroxine E growth hormone [52944]
Semester One Final Examinations, 2021 BIOM2052 Integrated Physiology and Pharmacology for Dentistry Page 5 of 22 6 Enlarged extremities and thickening soft tissues can be characteristic of which of the following endocrine disorders? [1.5 marks] A gigantism B prolactinomas C Addison’s disease D acromegaly E diabetes mellitus [55427] 7 Prolactin signalling involves [1.5 marks] A cyclic AMP B cyclic GMP C Janus kinase (JAK) D protein kinase A E phospholipase C [52945] 8 Which of the following statements is CORRECT in relation to the posterior pituitary hormones oxytocin and vasopressin? [1.5 marks] A Oxytocin and vasopressin are secreted by the large-bodied neurons of the hypothalamus and released into the median eminence B Oxytocin and vasopressin are secreted by the small-bodied neurons of the hypothalamus and released into the posterior pituitary C Oxytocin and vasopressin are expressed in both the supraoptic and paraventricular nuclei of the hypothalamus D A single hypothalamic neuron that produces oxytocin is also capable of producing vasopressin E Oxytocin and vasopressin bind to steroid receptors in their target cells for biological action [38383] 9 Which of the following statements is CORRECT with regard to the secretion of growth hormone? Growth hormone secretion is [1.5 marks] A continuous, but levels depend on pulse frequency or amplitude B pulsatile, and levels depend on pulse frequency and amplitude C continuous, and levels do not depend on pulse frequency or amplitude D pulsatile, but levels do not depend on pulse frequency or amplitude E continuous in response to activation by somatostatin [36989]
Semester One Final Examinations, 2021 BIOM2052 Integrated Physiology and Pharmacology for Dentistry Page 6 of 22 10 Which of the following statements is CORRECT regarding gonadal hormones? [1.5 marks] A Follicle stimulating hormone (FSH) inhibits the enzyme aromatase for the production of oestradiol from testosterone B Luteinising hormone (LH) activates the enzyme aromatase for the production of oestradiol from testosterone C Gonadotropin releasing hormone (GnRH) activates the enzyme aromatase for the production of oestradiol from progesterone D Luteinising hormone (LH) inhibits the enzyme aromatase for the production of oestradiol from testosterone E Follicle stimulating hormone (FSH) activates the enzyme aromatase for the production of oestradiol from testosterone [37168] 11 Which of the following statements about the metabolism of local anaesthetics is MOST correct? [1.5 marks] A Amide forms of local anaesthetics are metabolised in the liver by plasma esterases B Ester forms of local anaesthetics are metabolised by cytochrome P450 enzymes C Metabolism of local anaesthetics is independent of their structure D Amide and ester local anaesthetics may compete with each other for metabolism E Metabolism of esters occurs in the plasma and of amides in the liver [52807] 12 Local anaesthetics are not as effective when tissues are inflamed, because [1.5 marks] A tissue pH is more likely to be acidic, so the local anaesthetic is predominantly in the charged form B greater efficacy of anaesthetic block of signalling may impair voluntary movement C inflammation of the myelin sheath impairs absorption of the drug D nociceptor activation exceeds the ability of local anaesthetics to reduce signalling E inflammatory mediators render the local anaesthetic ineffective [52901] 13 Which of the following statements about general anaesthetics is CORRECT? [1.5 marks] A Actions of the general anaesthetics on cell membrane organisation and function appear to be more important than actions on cell membrane proteins B If a general anaesthetic is a potent analgesic, then it will be a potent skeletal muscle relaxant C Many potent volatile liquid general anaesthetics have low oil:H 2 O partition coefficients D Many general anaesthetics appear to exert their central nervous system depressant effects by acting on GABA-operated chloride channels E Isomers of various general anaesthetics have equal anaesthetic potency [15209]
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